Evidence map›Paper›PMID 42400635›Full record

ArticleEuropean radiology2026

Association of hypertension and blood pressure control with aneurysm wall enhancement in unruptured intracranial aneurysms: a multicenter propensity score-matched study.

Pengjun Jiang, Xin Nie, Mervyn D I Vergouwen, Jun Wu, Yi Yang, Zheng Wen, Yang Liu, Mahmud Mossa-Basha, Michael R Levitt, Bing Zhao and 11 more

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Article in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

21 authors.

Pengjun Jiang *Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xin Nie *Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Mervyn D I VergouwenDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Jun WuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yi YangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zheng WenDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yang LiuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Mahmud Mossa-BashaDepartment of Radiology, University of Washington, Seattle, WA, USA.
Michael R LevittDepartment of Radiology, University of Washington, Seattle, WA, USA.
Bing ZhaoDepartment of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jinrui RenDepartment of Neurosurgery, Shanxi Provincial People's Hospital, the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, China.
Xiaolin ChenDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yisen ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Hongye ZengDepartment of Radiology, University of Washington, Seattle, WA, USA.
Beibei SunDepartment of Radiology, University of Washington, Seattle, WA, USA.
Xinyi DongDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Xiaomeng LyuDepartment of Bioengineering, University of Washington, Seattle, WA, USA.
Rong WangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Shuo WangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Qingyuan LiuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. liuqingyuan@mail.ccmu.edu.cn.
Chengcheng ZhuDepartment of Radiology, University of Washington, Seattle, WA, USA. zhucheng@uw.edu.ORCID http://orcid.org/0000-0001-6898-549X

Funding

Basic Research Plan of Shanxi Province 20210302123351Beijing Natural Science Foundation of China 7234363Clinical Established Investigator grant by the Dutch Heart Foundation 2018T076National Natural Science Foundation of China 82401516National Natural Science Foundation of China 82471303Noncommunicable Chronic Diseases-National Science and Technology Major Project 2023ZD0505100United States National Heart, Lung and Blood Institute (NHLBI) grant R01HL162743
6 · The paper itself

Abstract

objectivesAneurysm wall enhancement (AWE) on 3T magnetic resonance aneurysm wall imaging (MR-AWI) predicts aneurysm growth and rupture during follow-up. However, its association with hypertension and the impact of blood pressure (BP) control remain unclear. This study aims to evaluate the association between hypertension, BP control, and AWE in patients with unruptured intracranial aneurysms (UIAs). MATERIALS AND

methodsWe retrospectively analyzed patients with UIAs from three prospective cohorts (IARP-CP, 100-Project, 100-Project II) who had 3.0 T MR-AWI. AWE was categorized into three patterns: no enhancement, focal enhancement, and circumferential enhancement. Hypertension was defined as a history of hypertension and/or use of antihypertensive drugs. Hypertensive patients were categorized as well-controlled (systolic BP [SBP] < 140 mmHg and diastolic BP [DBP] < 90 mmHg) or poorly controlled (SBP ≥ 140 mmHg or DBP ≥ 90 mmHg). Propensity score matching (PSM) (1:1) balanced confounders (age, sex, BMI, comorbidities, aneurysm characteristics). Ordinal logistic regression assessed associations between hypertension, BP control, and AWE.

resultsFrom a cohort of 1351 patients with 1416 UIAs who had MR-AWI, we matched 427 hypertensive patients with 427 normotensive patients. Hypertension was associated with higher AWE prevalence in both the total cohort (odds ratio (OR) 1.98, 95% CI: 1.57-2.51) and the matched cohort (OR 1.93, 95% CI: 1.49-2.49). Compared with normotensive patients, well-controlled hypertension (OR 1.72, 95% CI: 1.31-2.28) and poorly controlled hypertension (OR 2.58, 95% CI: 1.77-3.77) were linked to higher AWE prevalence.

conclusionHypertension, particularly poorly controlled hypertension, is associated with higher AWE prevalence in patients with UIAs, suggesting a potential link between BP status and aneurysm wall imaging characteristics, which warrants further longitudinal follow-up studies to clarify its clinical significance. KEY POINTS: Question Hypertension is a well-established risk factor for aneurysm rupture, but its association with aneurysm wall enhancement (AWE) and role of blood pressure control remain unknown. Findings This study found that hypertension, especially poorly controlled hypertension, is significantly associated with a higher prevalence of AWE in patients with unruptured intracranial aneurysms (UIAs). Clinical relevance This study underscores the importance of strict blood pressure control in UIA management, as it may mitigate vessel wall inflammation and subsequent risk of aneurysm progression and rupture.

Indexed as

Aneurysm wall enhancementBlood pressure controlHypertensionUnruptured intracranial aneurysm

Identifiers

PMID42400635

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