ArticleEuropean journal of nuclear medicine and molecular imaging2026
Glucagon-like peptide-1 receptor PET in indolent and aggressive insulinoma: Diagnostic performance, quantitative differences, and clinical implications.
Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate the diagnostic performance, quantitative characteristics, and clinical implications of Glucagon-Like Peptide-1 Receptor (GLP-1R) PET using
methodsIn this prospective study, patients presenting with hypoglycemia and fulfilling Whipple's triad were enrolled. All patients underwent
resultsNinety-six patients with suspected insulinoma were enrolled in this study (64 indolent, 25 aggressive insulinomas, and 7 non-insulinomas). For indolent insulinomas,
conclusionGLP-1R PET provides excellent diagnostic accuracy for indolent insulinomas but has reduced sensitivity in aggressive disease. In contrast, somatostatin receptor PET/CT is more effective for detecting aggressive tumors. GLP-1R-positive tumor burden may serve as a potential imaging biomarker for hypoglycemia control, supporting the complementary roles of these modalities in insulinoma management.
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