Evidence map›Paper›PMID 42400609›Full record

ArticleVirchows Archiv : an international journal of pathology2026

Adult sialoblastoma harbouring FGFR2 p.C382R gene mutation.

Amy Varner, Emilija Todorovic, Alena Skálová, Martin D Hyrcza

Abstract read
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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amy VarnerDepartment of Pathology and Laboratory Medicine, University of Calgary, Calgary, Canada.
Emilija TodorovicDepartment of Pathology and Laboratory Medicine, University of Calgary, Calgary, Canada.
Alena SkálováDepartment of Pathology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
Martin D HyrczaDepartment of Pathology and Laboratory Medicine, University of Calgary, Calgary, Canada. martin.hyrcza@ucalgary.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sialoblastoma is a rare salivary gland malignancy with most cases described in pediatric population. Adult presentation is rare, with only three cases reported to date in English literature. Recent molecular studies have identified recurrent activating FGFR2 p.C382R mutations in a subset of sialoblastomas, which appear to define a molecularly distinct group and may be associated with more aggressive behaviour. We report a basaloid parotid gland neoplasm in a 57-year-old man. The tumour showed solid basaloid morphology, high proliferative activity, and an immunophenotype overlapping with high-grade basaloid salivary gland carcinoma. Comprehensive molecular profiling identified FGFR2 p.C382R as a likely oncogenic driver, with no recurrent salivary gland fusion events detected. This case expands the limited literature on adult sialoblastoma and highlights the need to consider sialoblastoma in the differential diagnosis of basaloid salivary gland neoplasms in adults.

Indexed as

Basaloid salivary tumoursFGFR2 p.C382R mutationHigh grade salivary tumoursSalivary tumoursSialoblastomaUndifferentiated salivary tumours

Identifiers

PMID42400609

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.