ArticleThe Journal of organic chemistry2026
Access to Cyclic Monensin Derivatives via a Four-Component Ugi Reaction.
Article in The Journal of organic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Herein, we report the application of the Ugi four-component reaction as an efficient and versatile strategy for the synthesis of macrocyclic derivatives of monensin. The approach enables the incorporation of a peptidomimetic linker, significantly modulating the biological and cation complexation properties of the obtained compounds. All derivatives were obtained in crystalline form, allowing unambiguous structural elucidation by single-crystal X-ray diffraction, which revealed macrocyclic architectures stabilized by intramolecular hydrogen bonding.
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