Evidence map›Paper›PMID 42400511›Full record

ArticleInorganic chemistry2026

Stable Chelation of Zr-89 and Ac-225 with Dual Size-Selective Macrocyclic py

Mou Chakraborty, Kevin K Lee, Abbie Hasson, Thines Kanagasundaram, Amanda Fears, Aohan Hu, Justin J Wilson, Daniel L J Thorek

Abstract read
In one paragraph

Article in Inorganic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mou ChakrabortyDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0009-0002-8676-3086
Kevin K LeeDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID 0000-0002-1510-0237
Abbie HassonDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Thines KanagasundaramDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.
Amanda FearsDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Aohan HuDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID 0000-0002-9720-3159
Justin J WilsonDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID 0000-0002-4086-7982
Daniel L J ThorekDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0000-0003-2437-1239

Funding

The Radium-223 Combination Therapy Space; Improving Response and Clarifying ToxicitiesR01CA240711 · NCI · WASHINGTON UNIVERSITY · PI MICHALSKI, JEFF M., THOREK, DANIEL LYNDON JAFFE · 2020 to 2024
$2.2M
Opening the Therapeutic Window for PSMA-Targeted Molecular RadiotherapyR01CA229893 · NCI · WASHINGTON UNIVERSITY · PI THOREK, DANIEL LYNDON JAFFE · 2019 to 2024
$1.9M
Chelators to Enable Theranostic Alpha Particle Radiotherapeutic AgentsR56EB029259 · NIBIB · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI WILSON, JUSTIN J · 2024 to 2024
$532k
Antibiotic-based PET Imaging of Implant Associated Gram-positive Bacterial InfectionsR21EB034882 · NIBIB · WASHINGTON UNIVERSITY · PI THOREK, DANIEL LYNDON JAFFE · 2024 to 2024
$385k
NCI NIH HHS R01 CA229893NCI NIH HHS R01 CA240711NIBIB NIH HHS R21 EB034882NIBIB NIH HHS R56 EB029259
6 · The paper itself

Abstract

Radiotheranostic agents combine targeted therapeutics and diagnostic imaging, offering more efficient and personalized treatment strategies. Positron emission tomography provides high sensitivity and quantitative accuracy; however, its integration with α-particle radiotherapy remains limited by the lack of chelators capable of stabilizing radionuclides with widely different ionic radii.

Indexed as

ActiniumChelating AgentsCoordination ComplexesMacrocyclic CompoundsRadioisotopesRadiopharmaceuticalsZirconiumAnimalsHumansMicePositron-Emission TomographyTissue DistributionActiniumActinium-225Chelating AgentsCoordination ComplexesMacrocyclic CompoundsRadioisotopesRadiopharmaceuticalsZirconiumZirconium-89

Identifiers

PMID42400511
PMCPMC13390039

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.