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Gene expression in visceral adipocytes in metabolically healthy and unhealthy obesity: A cross-sectional analysis of associations with cardiometabolic components.
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22 authors.
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Abstract
ObjectiveVisceral adipose tissue (VAT) produces several adipokines; however, VAT adipocytes' gene expression has not been related with cardio-metabolic components. The present study aimed to explore associations between gene expression in human primary VAT adipocytes' and cardio-metabolic components in subjects who live with Metabolically Unhealthy Obesity (MUO) compared with subjects who live with Metabolically Healthy Obesity (MHO).MethodsCross-sectional study of patients who live with obesity, who underwent bariatric/metabolic surgery.ResultsForty-five patients (18 MHO and 27 MUO) aged 44 years, main co-morbidities Diabetes and Hypertension, were analyzed. MUO showed younger age and higher cardio-metabolic risk, as well as larger adipocyte´s sizes. Primary cultured adipocytes were isolated from trans-surgical VAT sample, then cDNA was analyzed for the expression of 92 genes, further distributed as MUO
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