ArticleJournal of medical virology2026
The Impact of Admission Viral Load and Inflammatory Markers on Mortality and Prognosis in Crimean-Congo Hemorrhagic Fever.
Article in Journal of medical virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
This study aimed to evaluate the impact of admission viral load and biochemical parameters on mortality and disease severity in a large cohort of patients with Crimean-Congo Hemorrhagic Fever (CCHF). This retrospective cohort study included 492 adult patients diagnosed with CCHF between 2022 and 2025. Admission viral loads, laboratory parameters, and clinical findings were compared. Logistic regression and ROC analyses were performed to identify independent predictors and optimal cut-off values. The mortality rate was 9.8% (n = 48). In multivariate analysis, admission log-viral load was identified as a potent independent predictor of mortality (OR: 3.36, p < 0.001 95% CI: 2.88-8.95, p < 0.001), alongside CRP (OR: 1.02, p < 0.001). Notably, advanced age was a significant risk factor, associated with a 2.8% increased risk of mortality (OR: 1.028, p = 0.025). In a separate model for disease severity, log-viral load (OR: 1.71, p < 0.001), age (OR: 1.021, p = 0.002), and CRP (OR: 1.012, p < 0.001) were significant independent predictors of a severe clinical course. Conversely, higher fibrinogen levels (OR: 0.997, p = 0.025) were associated with reduced disease severity. A viral load cut-off of 6.69 log
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