ArticleBiophysical journal2026
Tau protein differentially affects Piezo1 and Kir2.1 channels in brain capillary endothelial cells.
Article in Biophysical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Endothelial Piezo1 Hyperactivity Drives Neurovascular Dysfunction in Hypertension.Circulation research · 2026Article
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Authors and funding
2 authors.
Funding
Abstract
Accumulation of amyloid-β (Aβ) peptides and Tau proteins in the brain is a hallmark of neurodegeneration. Such build-up forms Aβ plaques and Tau neurofibrillary tangles, both of which are associated with synaptic loss, cognitive decline, and reduced cerebral blood flow in Alzheimer's disease (AD). Two ion channels in brain capillary endothelial cells (ECs)-the inwardly rectifying potassium channel Kir2.1 and the mechanosensitive channel Piezo1-are critical regulators of cerebral blood flow, and both display impaired activity in AD. Whether Aβ and Tau affect these channels remains incompletely understood. Using patch-clamp electrophysiology and freshly isolated mouse brain capillary ECs, we examined whether Aβ
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