ArticleActa obstetricia et gynecologica Scandinavica2026
Prospective evaluation of the Simple Fetal Medicine Foundation's first-trimester prediction model for preeclampsia in twin pregnancies.
Article in Acta obstetricia et gynecologica Scandinavica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionThere is no widely applicable prediction model for preeclampsia (PE) in twins, the existing models lack strict external validation. Therefore, this study aimed to evaluate the predictive performance of the Simple Fetal Medicine Foundation model (i.e., Simple FMF model, only including the maternal risk factors and mean arterial pressure [MAP]) for the prediction of PE at 11-13 MATERIAL AND
methodsThis was a prospective, non-intervention study in 464 twin pregnancies (including dichorionic twins and monochorionic twins) at 11-13
resultsAmong the 464 women included, 24.14% (112/464) developed PE, among which 1.29% (6/464) occurred before 30 weeks, 2.80% (13/464) occurred before 32 weeks, 6.47% (30/464) occurred before 34 weeks, 19.18% (89/464) occurred before 37 weeks, 4.96% (23/464) (including 21 cases of dichorionic diamniotic twins and 2 cases of monochorionic diamniotic twins) occurred at 37 weeks or later. The Simple FMF model had area under the receiver operating characteristic curves of 0.911 (95% confidence interval [CI]: 0.830-0.992), 0.799 (95% CI: 0.668-0.930), 0.797 (95% CI: 0.712-0.882), and 0.767 (95% CI: 0.706-0.828) for the screening of PE occurring before 30, 32, 34, and 37 weeks, respectively.
conclusionsThis study has demonstrated that the Simple FMF model was effective in predicting PE in twin pregnancies, especially for cases of PE occurring before 30, 32, 34, and 37 weeks. This approach only uses maternal characteristics, medical history, and MAP, making it suitable for implementation in resource-limited settings.
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