ArticleVeterinary research2026
From inserts to 3D spheroids: MAC-T and BME-UV1 co-culture models for in vitro reconstruction of the bovine mammary epithelial architecture.
Article in Veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Two bovine mammary epithelial cell lines, MAC-T and BME-UV1, were co-cultured either in Transwell® inserts or in 3D culture systems to comparatively investigate their potential to mimic the structure and function of a mammary alveolus. Using either Matrigel® or animal-friendly alternatives, i.e. rat collagen type I, a mixture of rat collagen type I and mouse laminin, Vitrogel® or matrix-free ultra-low attachment surfaces, both co-culture mammosphere development and tight junction formation were assessed. On Transwell® inserts, co-culture failed to establish a functional epithelial barrier. In contrast, varying patterns of cell-cell interaction and barrier organization emerged using the different 3D co-culture systems, providing new insights into the reconstruction of physiologically relevant and animal-friendly models of the bovine mammary gland.
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