ArticleBMC biology2026
An endogenous viral element of Aedes albopictus is translated and limits cognate virus.
Article in BMC biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe genomes of Aedes spp. mosquitoes host hundreds of non-retroviral endogenous viral elements (nrEVEs). The majority of nrEVEs are confined in piRNA clusters and produce P-element-induced wimpy testis-interacting RNAs (piRNAs), which were shown to be antiviral. Whether this is a universal mechanism or some nrEVEs have been exapted for antiviral functions as transcribed RNA or translated proteins remains unknown.
resultsWe identified 20 nrEVEs located outside piRNA clusters and encompassing complete viral open reading frame in the genome of the Asian tiger mosquito Aedes albopictus. By integrating in vivo and in vitro experimental approaches using Aag2 cells, we provide evidence suggesting that one nrEVE, designated Flavi24, is translated in adult mosquitoes and contributes to controlling cognate viral infection.
conclusionOur results expand the functions of Ae. albopictus nrEVEs suggesting they can regulate host-virus interactions through various mechanisms.
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