Evidence map›Paper›PMID 42399999›Full record

ReviewParasites & vectors2026

Immune-reproductive cross talk in mosquitoes: molecular pathways and energy homeostasis.

Feifei Zheng, Caizhi Zhao, Xin Li, Tingting Liu, Shun Wang, Zhilong Liu, Shasha Yu, Ying Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Parasites & vectors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Feifei Zheng *Department of Tropical Medicine, College of Military Preventive Medicine, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China.
Caizhi Zhao *Department of Tropical Medicine, College of Military Preventive Medicine, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China.
Xin LiDepartment of Tropical Medicine, College of Military Preventive Medicine, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China.
Tingting LiuDepartment of Tropical Medicine, College of Military Preventive Medicine, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China.
Shun WangDepartment of Tropical Medicine, College of Military Preventive Medicine, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China.
Zhilong LiuDepartment of Tropical Medicine, College of Military Preventive Medicine, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China.
Shasha YuDepartment of Tropical Medicine, College of Military Preventive Medicine, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China. yushasha@tmmu.edu.cn.
Ying WangDepartment of Tropical Medicine, College of Military Preventive Medicine, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China. wangyingtmmu2016@126.com.

Funding

the National Nature Science Foundation of China NO. 82472319
6 · The paper itself

Abstract

In the field of global health, mosquito-borne infectious diseases (such as malaria, dengue fever, and Zika) remain serious public health concerns. Recent research has emphasized that mosquitoes must coordinate their reproductive output and immune defenses under limited energy and nutritional conditions, forming a tightly regulated trade-off. This process involves complex signaling pathways and stage-specific molecular mechanisms. Key factors, such as juvenile hormone (JH), 20-hydroxyecdysone (20E), autophagy pathways, immune-regulatory genes, and metal ions, can potentially influence this equilibrium state, thereby either promoting or inhibiting the occurrence and development of mosquito-borne infectious diseases. However, the exact mechanism underlying this regulation remains unclear. This review summarizes recent findings on how these components interact at the molecular and physiological levels, with the aim of developing a rational framework for identifying potential molecular targets and developing new strategies for vector control.

Indexed as

CulicidaeEnergy MetabolismHomeostasisMosquito VectorsAnimalsAutophagyEcdysteroneHumansJuvenile HormonesMosquito-Borne DiseasesReproductionSignal TransductionEcdysteroneJuvenile Hormones20-hydroxyecdysoneAutophagyImmunityJuvenile hormoneMetal ionsReproduction

Identifiers

PMID42399999
PMCPMC13602775

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.