ArticleJournal of medical case reports2026
The paradox of benign histology and malignant behavior: lymphatic metastasis in pleomorphic adenoma-a case report.
Article in Journal of medical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetastasizing pleomorphic adenoma is an exceptionally rare variant of salivary gland neoplasms that maintains histologically benign features while demonstrating metastatic behavior. Lymph node involvement is particularly uncommon, representing only 20.1% of reported metastatic cases. CASE PRESENTATION: A 31-year-old Iranian female patient presented with a progressively enlarging left cervical mass developing over 4 years. Her history included surgical excision of a pleomorphic adenoma 12 years prior. Ultrasonography revealed a complex multinodular mass within the submandibular salivary gland and distinct lymphadenopathy in the left lateral neck. Surgical excision and histopathological examination confirmed metastasizing pleomorphic adenoma with lymph node involvement, maintaining characteristic benign cytological features despite its metastatic presentation.
conclusionThis case of metastasizing pleomorphic adenoma, occurring after a 12-year latency period, clinically supports the contemporary hypothesis that a long incubation time of residual disease, rather than recurrence itself, is a critical factor for metastatic transformation. The report contributes to the limited literature on the lymphatic dissemination of this tumor and powerfully underscores that indefinite long-term surveillance is mandatory for all patients with a history of pleomorphic adenoma. Finally, it highlights the diagnostic paradox that persists when advanced molecular testing is unavailable, reinforcing that clinical vigilance is paramount regardless of a benign histological report.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.