Evidence map›Paper›PMID 42399976›Full record

ArticleVirology journal2026

Genomic insights into influenza A(H1N1)pdm09 virus evolution in Yunnan province, China, during 2018-2023.

Meiling Zhang, Xiuping Zhang, Ruize Ni, Yaoyao Chen, Xiaonan Zhao, Jienan Zhou, Yanhong Sun, Xiaoyu Han, Zhaosheng Liu, Chunrui Luo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Meiling Zhang *Department of Acute Infectious Diseases Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming, 650500, China.
Xiuping Zhang *State Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650201, China.
Ruize Ni *Department of Acute Infectious Diseases Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming, 650500, China.
Yaoyao ChenDepartment of Acute Infectious Diseases Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming, 650500, China.
Xiaonan ZhaoDepartment of Acute Infectious Diseases Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming, 650500, China.
Jienan ZhouDepartment of Acute Infectious Diseases Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming, 650500, China.
Yanhong SunDepartment of Acute Infectious Diseases Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming, 650500, China.
Xiaoyu HanDepartment of Acute Infectious Diseases Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming, 650500, China.
Zhaosheng LiuDepartment of Acute Infectious Diseases Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming, 650500, China.
Chunrui LuoDepartment of Acute Infectious Diseases Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming, 650500, China.
Xiaoqing FuDepartment of Acute Infectious Diseases Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming, 650500, China.
Yong ShaoState Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650201, China. shaoyong@mail.kiz.ac.cn.ORCID https://orcid.org/0000-0003-1704-8425

Funding

CAS Youth Innovation Promotion Association 2023404Young Academic and Technical Leader Raising Foundation of Yunnan Province 202305AC160031
6 · The paper itself

Abstract

Research on regional circulation and evolution of influenza A viruses before and after the COVID-19 pandemic is crucial for informing vaccine updates and antiviral drug development. This study generated 260 new genomic sequences of influenza A(H1N1)pdm09 viruses collected in Yunnan province, China, between 2018 and 2023. Comparative genomics analyses elucidated their evolutionary characteristics and dynamics. Epidemiological analysis identified key risk factors (sex, age, occupation) for influenza infection. Phylogenetic analyses revealed the sequence divergences between the vaccine strains and Yunnan circulating strains, especially in the 2020-2024 influenza seasons. The subclade reassortment events were extremely limited among these sequenced Yunnan strains, suggesting the reassortment may be not a major contributor for the circulation and evolution of influenza A(H1N1)pdm09 viruses in Yunnan during these influenza seasons. We detected the elevated evolutionary pressures acting on the specific gene segments, reflected in increased d

Indexed as

Evolution, MolecularGenome, ViralInfluenza A Virus, H1N1 SubtypeInfluenza, HumanAmino Acid SubstitutionChinaGenomicsHemagglutinin Glycoproteins, Influenza VirusHumansNeuraminidasePhylogenyReassortant VirusesHemagglutinin Glycoproteins, Influenza VirusNeuraminidaseAdaptationEvolutionary characteristicsInfluenza A(H1N1)pdm09 virusReassortmentYunnan province

Identifiers

PMID42399976
PMCPMC13602790

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.