SynthesisBMC oral health2026
How dietary interventions impact oral conditions: a systematic review.
Synthesis in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
backgroundOral diseases, including periodontal disease, salivary gland dysfunction and oral squamous cell carcinoma, are characterized by chronic inflammation and metabolic dysregulation. Dietary interventions have demonstrated systemic anti-inflammatory and metabolic benefits; however, their effects on the oral cavity remain insufficiently explored.
methodsA systematic review was conducted in PubMed and Web of Science to identify relevant studies published up to September 2025 assessing the effects of fasting, caloric restriction, and ketogenic diet on oral conditions. The search strategy combined MeSH terms and keywords related to these dietary interventions and oral health conditions. Data on study characteristics, interventions, outcomes, and limitations were extracted and synthesized.
resultsFourteen studies were included, comprising preclinical in vitro and in vivo studies as well as a limited number of clinical trials. Caloric restriction and intermittent fasting were generally associated with improvements in periodontal inflammation and metabolic parameters, without significant effects on oral microbiota composition. Alternate-day fasting demonstrated beneficial effects on salivary gland function and inflammatory responses in preclinical models. In oral squamous cell carcinoma, fasting-related interventions enhanced treatment sensitivity and reduced tumor growth in experimental studies; however, clinical evidence remains scarce, and feasibility, particularly for ketogenic diet, is limited and mainly derived from small pilot studies with methodological constraints.
conclusionCaloric restriction and intermittent fasting may exert potential beneficial effects in oral health by modulating inflammation, tissue regeneration, and metabolic pathways. However, current evidence remains largely preclinical and heterogeneous. Well-designed clinical trials and mechanistic studies in humans are required to establish their clinical relevance and to support their integration into evidence-based oral health practice. REVIEW REGISTRATION: This review was registered in PROSPERO (Registration ID: 1085293) and conducted in accordance with PRISMA 2020 guidelines [1].
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