Evidence map›Paper›PMID 42399903›Full record

ArticleBMC cancer2026

Plexin A2 regulated the metastasis in breast cancer through MCM7.

Chenghong Xiang, Xiao Chen, Fei Mo, Zhaoming Zhong, Qiye Wang, Deyu Kong, Jun Deng, Min Hong

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Article in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Chenghong Xiang *Department of medical oncology, The first affiliated hospital of Kunming medical University, No.295 Xichang Rd, Kunming, Yunnan, 650032, China.
Xiao Chen *Department of medical oncology, The first affiliated hospital of Kunming medical University, No.295 Xichang Rd, Kunming, Yunnan, 650032, China.
Fei MoDepartment of medical oncology, The first affiliated hospital of Kunming medical University, No.295 Xichang Rd, Kunming, Yunnan, 650032, China.
Zhaoming ZhongDepartment of medical oncology, The first affiliated hospital of Kunming medical University, No.295 Xichang Rd, Kunming, Yunnan, 650032, China.
Qiye WangDepartment of medical oncology, The first affiliated hospital of Kunming medical University, No.295 Xichang Rd, Kunming, Yunnan, 650032, China.
Deyu KongDepartment of medical oncology, The first affiliated hospital of Kunming medical University, No.295 Xichang Rd, Kunming, Yunnan, 650032, China.
Jun DengDepartment of medical oncology, The first affiliated hospital of Kunming medical University, No.295 Xichang Rd, Kunming, Yunnan, 650032, China. 383136221@qq.com.
Min HongDepartment of medical oncology, The first affiliated hospital of Kunming medical University, No.295 Xichang Rd, Kunming, Yunnan, 650032, China. hongmin@ydyy.cn.

Funding

Yunnan Fundamental Research Kunming Medical University Projects 202401AY070001-094
6 · The paper itself

Abstract

Breast cancer is a malignant tumour that affects women's health. In clinical practice, breast cancer is mainly treated by surgery, radiation, and drugs, but the risk of metastasis and recurrence is high, and metastasis is inextricably linked to the transcription and regulation of many molecule. In this manuscript, we first found 27 highly expressed genes and 58 lower expressed genes related to metastasis, then Plexin A2 was found highly expressed in the tissues from metastasis breast cancer and exerted as promote role in cell proliferation, migration, and invasion of MDA-MB-231. Also, CoIP-MS was used to detect the proteins which bind with Plexin A2 and differential expressed in highly metastasis MDA-MB-231 and 9 proteins were selected in highly invasion MDA-MB-231. Plexin A2 was found bind with MCM7 in a binding set of S45 through a phosphoserine/threonine binding group in highly metastasis MDA-MB-231. Moreover, Plexin A2 and MCM7 was found involved in cell proliferation, apoptosis inhibition, migration, and invasion of MDA-MB-231. In conclusion, Plexin A2 bind with MCM7 in a binding set of S45 through a phosphoserine/threonine binding group, Plexin A2 and MCM7 was involved in cell proliferation, apoptosis inhibition, migration, and invasion of MDA-MB-231. These results showed that Plexin A2 can be considered as a promising biomarker in breast cancer metastasis.

Indexed as

Breast NeoplasmsMinichromosome Maintenance Complex Component 7Nerve Tissue ProteinsApoptosisCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMDA-MB-231 CellsNeoplasm InvasivenessNeoplasm MetastasisMinichromosome Maintenance Complex Component 7Nerve Tissue ProteinsBreast cancerMCM7MetastasisPlexin A2

Identifiers

PMID42399903

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