ArticleBMC oral health2026
Comparative evaluation of oral misoprostol and low-level laser therapy in orthodontic tooth movement in a rat model.
Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundTo investigate the effects of low-level laser therapy and misoprostol on orthodontic tooth movement (OTM), external root resorption, root length, alveolar bone mineral density (BMD), and osteoclast activity.
methodsThirty-six female Wistar albino rats were divided into misoprostol, laser, and control groups. OTM was induced using a nickel-titanium closed-coil spring between the maxillary incisor and first molar for 21 days. Following euthanasia, tooth displacement, root length, root resorption, and BMD were analyzed using micro-computed tomography. BMD was assessed around the mesial root in tension, compression, apical mesial, and apical distal regions. Osteoclastic activity was evaluated immunohistochemically.
resultsThe laser and misoprostol groups showed greater OTM than the control group, without statistical significance (p > 0.05). Root length and root resorption did not differ significantly among groups (p > 0.05). BMD values were similar across groups (p > 0.05), although within-group comparisons showed higher values in tension areas and lower values in compression areas. Osteoclast counts were significantly higher in the laser group (p < 0.05).
conclusionsUnder the conditions of this study, low-level laser therapy did not result in a statistically significant increase in tooth movement; however, it may influence the cellular mechanisms underlying orthodontic tooth movement, as reflected by increased osteoclast activity, and may modulate bone remodeling without increasing root resorption. Although BMD tended to decrease in the compression areas and increase in the tension areas, the findings were inconsistent in the apical regions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.