Evidence map›Paper›PMID 42399736›Full record

ArticleBMC research notes2026

Sleep deprivation impairs gastric ulcer healing and induces anxiety-like behavior in rats.

Omosola Fisayo Anifowose, Moshood Abiola Folawiyo, Temitope Elizabeth Olabiyi, Oluwabunmi Grace Benson, Durotioluwa Lois Olu-Agbede, Gbenga Sunday Adeleye, Oluwatomisin Olalekan Faniyan, Kehinde Samuel Olaniyi

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Article in BMC research notes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Omosola Fisayo AnifowoseDepartment of Physiology, Faculty of Basic Medical Sciences, Ekiti State University, Ado-Ekiti, Nigeria. omosola.anifowose@eksu.edu.ng.
Moshood Abiola FolawiyoDepartment of Physiology, Faculty of Basic Medical Sciences, Ekiti State University, Ado-Ekiti, Nigeria.
Temitope Elizabeth OlabiyiDepartment of Physiology, Faculty of Basic Medical Sciences, Ekiti State University, Ado-Ekiti, Nigeria.
Oluwabunmi Grace BensonDepartment of Physiology, Faculty of Basic Medical Sciences, Ekiti State University, Ado-Ekiti, Nigeria.
Durotioluwa Lois Olu-AgbedeDepartment of Physiology, Faculty of Basic Medical Sciences, Ekiti State University, Ado-Ekiti, Nigeria.
Gbenga Sunday AdeleyeDepartment of Physiology, Faculty of Basic Medical Sciences, Ekiti State University, Ado-Ekiti, Nigeria.
Oluwatomisin Olalekan FaniyanDepartment of Physiology, International School of Advanced Studies, University of Camerino, Camerino, Italy.
Kehinde Samuel OlaniyiCardio/Endo-Metabolic and Epigenetic Research Unit, Department of Physiology, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Nigeria. olaniyisk@abuad.edu.ng.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study investigated the effects of total sleep deprivation (SD) on gastric ulcer (GU) healing, anxiety-like behavior, neuro-oxidative stress, antioxidant defenses, and prefrontal cortical histoarchitecture in male Wistar rats.

resultsSD exacerbated weight loss, elevated corticosterone levels, ulcer area, and delayed GU healing. Ulcer+sleep-deprived rats exhibited increased thigmotaxis, reduced center exploration, locomotion, and rearing. Biochemical analyses revealed sustained malondialdehyde elevation and decreased antioxidant activity. Histology demonstrated progressive prefrontal cortex neurodegeneration, most severe in ulcer+sleep-deprived group by day 14. These findings demonstrates that SD during GU healing intensifies neuro-oxidative stress, disrupts antioxidant defenses, aggravates anxiety-like behavior and promotes neurodegeneration, collectively delaying gastric-mucosal repair.

Indexed as

AnxietyBehavior, AnimalSleep DeprivationStomach UlcerWound HealingAnimalsCorticosteroneGastric MucosaMaleMalondialdehydeOxidative StressPrefrontal CortexRatsRats, WistarCorticosteroneMalondialdehydeBrainCorticosteroneGastric ulcerOxidative stressSleep deprivation

Identifiers

PMID42399736
PMCPMC13599305

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.