Evidence map›Paper›PMID 42399711›Full record

ArticleScientific reports2026

Therapeutic potential of crude protein extracts from two Egyptian freshwater snails Lanistes carinatus and Bellamya unicolor.

Mohamed R Habib, Azza H Mohamed, AbdElhafez R AbdElhafez, Mohamed S Helmy, Ahmed A Hamed, Aya I F Akila, Hesham R El-Seedi, Shaden A M Khalifa, Hassan M Masoud

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Mohamed R HabibMedical Malacology Department, Theodor Bilharz Research Institute, 1 Corniche El Nile St., Warrak El-Haddar, Imbaba, Giza, 12411, Egypt.
Azza H MohamedZoology Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt.
AbdElhafez R AbdElhafezZoology Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt.
Mohamed S HelmyMolecular Biology Department, National Research Centre, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt.
Ahmed A HamedMicrobial Chemistry Department, National Research Center, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt.
Aya I F AkilaDepartment of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom, 31100107, Egypt.
Hesham R El-SeediDepartment of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom, 31100107, Egypt.
Shaden A M KhalifaNeurology and Psychiatry Department, Capio Saint Göran's Hospital, Sankt Göransplan 1, 112 19, Stockholm, Sweden.
Hassan M MasoudMolecular Biology Department, National Research Centre, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt. hssnmasoud@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Freshwater snails are emerging sources of bioactive molecules with potential biomedical and therapeutic relevance. This study evaluated crude protein extracts from two Egyptian freshwater snails, Lanistes carinatus and Bellamya unicolor, for antioxidant enzymes, antimicrobial and antibiofilm activities, cytotoxicity against human cancer cell lines, and peptide composition. Both species exhibited low activities of superoxide dismutase (SOD), catalase (CAT), and glutathione S-transferase (GST), with slightly higher levels in L. carinatus. Despite this, the crude protein extracts inhibited the growth of Escherichia coli and Staphylococcus aureus; L. carinatus showed stronger antifungal activity against Candida albicans, while neither extract affected Aspergillus niger. Selective cytotoxicity was observed: L. carinatus was most active against MCF-7 and HeLa cells, whereas B. unicolor was highly potent against HCT-116 and moderately active against PC3 cells, with minimal effects on normal WI-38 cells. LC-MS/MS identified 26 short peptides, likely contributing to the antimicrobial and anticancer activities.These findings provide preliminary evidence of the therapeutic potential of L. carinatus and B. unicolor crude protein extracts, highlighting freshwater snails as candidate sources of bioactive molecules that merit further investigation.

Indexed as

Anti-Infective AgentsComplex MixturesProteinsSnailsAnimalsAntineoplastic AgentsAntioxidantsCandida albicansCell Line, TumorEgyptFresh WaterHeLa CellsHumansStaphylococcus aureusAnti-Infective AgentsAntineoplastic AgentsAntioxidantsComplex MixturesProteinsAntibiofilm activityAntimicrobial activityAntioxidant enzymesBellamya unicolorBioactive peptidesCytotoxicityFreshwater snailsLanistes carinatus

Identifiers

PMID42399711
PMCPMC13332020

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