Evidence map›Paper›PMID 42399669›Full record

ArticleNature plants2026

Epigenetic regulation of TaFIP phytocytokine clusters confers basal resistance via receptor kinase TaFIPR in wheat.

Zunyong Liu, Xin Chen, Zishu Xu, Guiping Zhang, Mingyu Chen, Yun Chen, Zhonghua Ma

Abstract read
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In one paragraph

Article in Nature plants, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zunyong Liu *Institute of Biotechnology, National Key Laboratory of Rice Biological Breeding, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou, China. zunyliu@zju.edu.cn.ORCID http://orcid.org/0000-0001-9893-4925
Xin Chen *Institute of Biotechnology, National Key Laboratory of Rice Biological Breeding, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou, China.
Zishu Xu *Institute of Biotechnology, National Key Laboratory of Rice Biological Breeding, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou, China.
Guiping ZhangInstitute of Biotechnology, National Key Laboratory of Rice Biological Breeding, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou, China.
Mingyu ChenInstitute of Biotechnology, National Key Laboratory of Rice Biological Breeding, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou, China.
Yun ChenInstitute of Biotechnology, National Key Laboratory of Rice Biological Breeding, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou, China.
Zhonghua MaInstitute of Biotechnology, National Key Laboratory of Rice Biological Breeding, Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou, China. zhma@zju.edu.cn.ORCID http://orcid.org/0000-0002-5426-0997

Funding

Natural Science Foundation of Zhejiang Province (Zhejiang Provincial Natural Science Foundation) LR25C140001
6 · The paper itself

Abstract

In both plant and animal innate immunity, rapid biosynthesis of cytokine-like peptides is essential for activating immune responses through plasma membrane receptor kinases. Peptide homeostasis is tightly controlled at multiple regulatory levels to avoid adverse effects caused by excessive phytocytokine production. However, the mechanisms underlying the rapid transition between transcriptional activation and repression of phytocytokine genes in response to immune stimuli remain largely unknown. Here we identify previously uncharacterized phytocytokine clusters in wheat, termed TaFIPs, which are rapidly induced by Fusarium infection. TaFIP genes are epigenetically regulated by H3K4me3 and H3K27me3 bivalent histone marks enabling rapid transcriptional shifts. Functionally, the leucine-rich repeat receptor kinase TaFIPR directly recognizes and binds TaFIPs to activate multiple immune responses, thereby enhancing wheat resistance to Fusarium infection. Our findings reveal an epigenetic mechanism that fine-tunes phytocytokine-mediated immunity in wheat.

Indexed as

CytokinesDisease ResistanceEpigenesis, GeneticPlant DiseasesPlant ImmunityPlant ProteinsTriticumFusariumGene Expression Regulation, PlantCytokinesPlant Proteins

Identifiers

PMID42399669

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.