Evidence map›Paper›PMID 42399642›Full record

ArticleCell death and differentiation2026

A planar dimer of bovine ATP synthase.

Chimari Jiko, Atsuki Nakano, Yosuke Teshirogi, Eiki Yamashita, Genji Kurisu, Daron Standley, Tohru Terada, Kaoru Mitsuoka, Ken Yokoyama, Christoph Gerle

Abstract read
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In one paragraph

Article in Cell death and differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chimari Jiko *Frontier Research Project on Integrated Radiation and Nuclear Science, Institute for Integrated Radiation and Nuclear Science, Kyoto University, Kumatori, Osaka, Japan.ORCID http://orcid.org/0009-0009-9880-9804
Atsuki Nakano *Department of Molecular Biosciences, Kyoto Sangyo University, Kamigamo-Motoyama, Kita-ku, Kyoto, Japan.ORCID http://orcid.org/0000-0003-2466-5341
Yosuke Teshirogi *Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, Japan.ORCID http://orcid.org/0009-0003-3205-7343
Eiki YamashitaInstitute for Protein Research, The University of Osaka, 3-2 Yamadaoka, Suita, Osaka, Japan.ORCID http://orcid.org/0000-0002-4278-0039
Genji KurisuInstitute for Protein Research, The University of Osaka, 3-2 Yamadaoka, Suita, Osaka, Japan.ORCID http://orcid.org/0000-0002-5354-0807
Daron StandleyDepartment of Genome Informatics, Research Institute for Microbial Diseases, The University of Osaka, Suita, Osaka, Japan.ORCID http://orcid.org/0000-0003-4078-0817
Tohru TeradaDepartment of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-7091-0646
Kaoru MitsuokaResearch Center for Ultra-High Voltage Electron Microscopy, The University of Osaka, Ibaraki, Osaka, Japan.ORCID http://orcid.org/0000-0003-1782-675X
Ken YokoyamaDepartment of Molecular Biosciences, Kyoto Sangyo University, Kamigamo-Motoyama, Kita-ku, Kyoto, Japan. yokoken@cc.kyoto-su.ac.jp.ORCID http://orcid.org/0000-0002-6813-1096
Christoph GerleLife Science Research Infrastructure Group, RIKEN SPring-8 Center, Kouto, 1-1-1, Sayo, Hyogo, Japan. christoph.gerle@riken.jp.ORCID http://orcid.org/0000-0002-7265-2804

Funding

Japan Agency for Medical Research and Development (AMED) JP25am0101001Japan Agency for Medical Research and Development (AMED) JP25ama121001Japan Agency for Medical Research and Development (AMED) JP25ama121027MEXT | Japan Society for the Promotion of Science (JSPS) 19K15749MEXT | Japan Society for the Promotion of Science (JSPS) 20J40167
6 · The paper itself

Abstract

Mammalian mitochondrial ATP synthase typically organizes into rows of V-shaped dimers that impose significant membrane curvature essential for mitochondrial cristae formation. Using gentle, column-free purification combined with single-particle cryo-electron microscopy, we have identified a previously unrecognized planar dimeric form of bovine ATP synthase exhibiting minimal membrane bending. This planar dimer is characterized structurally by anti-parallel arrangement of two ATP synthase complexes linked by a straight conformation of inhibitory factor 1 (IF1), a sharp contrast to the kinked IF1 observed in tetrameric assemblies. Molecular dynamics simulations confirm that transitioning between straight and kinked IF1 conformations occurs without significant energetic barriers. The planar dimer also displays distinct peripheral stalk positioning relative to its adjacent α subunit. These structural divergences suggest a specialized function and a distinct localization for planar ATP synthase dimers, providing structural support for a division of labor within mitochondrial ATP synthase populations.

Identifiers

PMID42399642

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.