Evidence map›Paper›PMID 42399621›Full record

ArticleNature communications2026

Structural basis of the regulation by CDK11 kinase of early spliceosome activation and evidence for its proofreading by DHX15 helicase.

Zhenwei Zhang, Vinay Kumar, Sumeru Panta, Jiayun Zhong, Olexandr Dybkov, Haohao Dong, Berthold Kastner, Henning Urlaub, Holger Stark, Reinhard Lührmann

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhenwei Zhang *State Key Laboratory of Biotherapy and Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China.ORCID 0000-0003-2906-9346
Vinay Kumar *Emeritus Group Cellular Biochemistry, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID 0000-0001-6642-8876
Sumeru PantaDepartment of Structural Dynamics, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany.
Jiayun ZhongState Key Laboratory of Biotherapy and Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China.
Olexandr DybkovBioanalytical Mass Spectrometry, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID 0000-0001-6005-7242
Haohao DongState Key Laboratory of Biotherapy and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.ORCID 0000-0002-5022-3494
Berthold KastnerEmeritus Group Cellular Biochemistry, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID 0000-0002-6051-0198
Henning UrlaubBioanalytical Mass Spectrometry, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID 0000-0003-1837-5233
Holger StarkDepartment of Structural Dynamics, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany. hstark1@gwdg.de.
Reinhard LührmannEmeritus Group Cellular Biochemistry, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany. reinhard.luehrmann@mpinat.mpg.de.ORCID 0000-0003-3253-7518

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) SFB1565Deutsche Forschungsgemeinschaft (German Research Foundation) SFB1565, project number 469281184National Natural Science Foundation of China (National Science Foundation of China) NSFC 32300442Sichuan University (SCU) YJ202344
6 · The paper itself

Abstract

Formation of the activated human spliceosome (B

Indexed as

Cyclin-Dependent KinasesDEAD-box RNA HelicasesRNA HelicasesRNA Splicing FactorsSpliceosomesCryoelectron MicroscopyHumansPhosphoproteinsPhosphorylationRibonucleoprotein, U2 Small NuclearRNA SplicingCyclin-Dependent KinasesDEAD-box RNA HelicasesPhosphoproteinsRibonucleoprotein, U2 Small NuclearRNA HelicasesRNA Splicing FactorsSF3B1 protein, human

Identifiers

PMID42399621
PMCPMC13332222

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.