Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Photobiomodulation to prevent oral mucositis and physical function impairments after hematopoietic cell transplantation: POMFITT randomized trial.
Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06260111 (Laser Photobiomodulation to Prevent Oral Mucositis and Functional Impairment Among Adult Hematologic Cancer Patients Undergoing Hematopoietic Stem Cell Transplantation), which is not on this map. Not yet cited in PubMed.
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Laser Photobiomodulation to Prevent Oral Mucositis and Functional Impairment Among Adult Hematologic Cancer Patients Undergoing Hematopoietic Stem Cell Transplantation
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo assess the effectiveness of photobiomodulation, compared to standard care, to prevent oral mucositis and functional impairment, and improve quality of life in adults who underwent hematopoietic cell transplantation (HCT).
methodsRandomized, controlled clinical trial with 30 patients with hematologic malignancies.
interventionInGaIP diode laser treatment, starting on the first day of conditioning until day + 3, three times a week. PARAMETERS: wavelengths of 660 nm and 808 nm, 100 mW, 2 J, 20 points. OUTCOME MEASURES: oral mucositis (WHO scale), functional capacity (2-min step test), handgrip strength (Jamar dynamometer), lower limb strength (Sit-to-Stand test), quality of life (FACT-BMT), and acceptance (0-10 numerical scale).
resultsParticipants fully adhered to the intervention (n = 15; 100%). Acceptance was rated 10/10 by 93.3% of participants. Severe oral mucositis occurred in 26.6% of the control group and 0% of the photobiomodulation group (p = 0.032). No significant differences were found between the groups in hospitalization days, handgrip strength, aerobic capacity, or lower-limb strength.
conclusionsPhotobiomodulation was associated with a lower occurrence of severe oral mucositis but did not affect physical function or quality of life at discharge. Acceptance in the Chilean context was very high.
trial registrationClinicalTrials.gov: NCT06260111.
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