ReviewNature chemical biology2026
Artificial metalloenzymes in complex biological environments.
Review in Nature chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Artificial metalloenzymes (ArMs) are proteins engineered to contain metal cofactors that often catalyze chemical reactions rarely or never observed in natural biological processes. They hold promise for applications including fine-chemical production, control of cellular function and therapeutics. Many of these applications are difficult to achieve due to cofactor inactivation in complex biological environments and cofactor-induced cellular stress. In this study, I explore the most recent strategies for developing robust, biocompatible ArMs that function in cell lysates, on cell surfaces or intracellularly. The pros and cons of developing and using ArMs in these three environments are described. I also examine how active ArMs might tolerate their environment, and the outstanding challenges and opportunities, including the need for simple methods of construction, improved catalytic performance and exploration of other reactions and microorganisms.
Indexed as
Identifiers
42399451What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.