Evidence map›Paper›PMID 42399420›Full record

ArticleNature cardiovascular research2026

Depth of neutrophil mobilization stratifies survival in ST-elevation myocardial infarction.

Mathis Richter, Jessica von Göwels, Maximilian Fähndrich, Christian Lipgens Fernandez, Katharina Grohn, Marius Welzel, Dennis Schwarz, Alexander Lang, Amin Polzin, Sara Reinartz Groba and 31 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cardiovascular research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Mathis RichterInstitute of Experimental Pathology (ExPat), Center of Molecular Biology of Inflammation (ZMBE), University of Münster, Münster, Germany. mathis.richter@uni-muenster.de.ORCID http://orcid.org/0000-0002-3110-6137
Jessica von Göwels *Institute of Experimental Pathology (ExPat), Center of Molecular Biology of Inflammation (ZMBE), University of Münster, Münster, Germany.ORCID http://orcid.org/0009-0008-6591-1709
Maximilian Fähndrich *Institute of Experimental Pathology (ExPat), Center of Molecular Biology of Inflammation (ZMBE), University of Münster, Münster, Germany.
Christian Lipgens Fernandez *Institute of Experimental Pathology (ExPat), Center of Molecular Biology of Inflammation (ZMBE), University of Münster, Münster, Germany.
Katharina Grohn *Institute of Experimental Pathology (ExPat), Center of Molecular Biology of Inflammation (ZMBE), University of Münster, Münster, Germany.
Marius WelzelInstitute of Medical Informatics, University of Münster, Münster, Germany.
Dennis SchwarzInstitute of Experimental Pathology (ExPat), Center of Molecular Biology of Inflammation (ZMBE), University of Münster, Münster, Germany.
Alexander LangDepartment of Cardiology, Pulmonology and Vascular Medicine, University Hospital and Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.ORCID http://orcid.org/0000-0001-6006-7109
Amin PolzinDepartment of Cardiology, Pulmonology and Vascular Medicine, University Hospital and Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
Sara Reinartz GrobaInstitute of Experimental Pathology (ExPat), Center of Molecular Biology of Inflammation (ZMBE), University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0003-1045-2580
Luca FarinolaInstitute of Experimental Pathology (ExPat), Center of Molecular Biology of Inflammation (ZMBE), University of Münster, Münster, Germany.
Susmita GhoshLeibniz-Institut für Analytische Wissenschaften ISAS - e.V., Dortmund, Germany.
Jan-Niklas HemingDepartment of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.ORCID http://orcid.org/0009-0007-2434-8553
Hanna AlethInstitute of Molecular Tumour Biology, University of Münster, Münster, Germany.
Anastassia AkhalkatsiDepartment of Medicine I, University Hospital, LMU Munich, Munich, Germany.
Kian MarjaniDepartment of Cardiology, Pulmonology and Vascular Medicine, University Hospital and Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.ORCID http://orcid.org/0000-0003-1387-5319
Nicole RübsamenInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Tobias RadeckeInstitute of Experimental Pathology (ExPat), Center of Molecular Biology of Inflammation (ZMBE), University of Münster, Münster, Germany.
Frank RosenbauerInstitute of Molecular Tumour Biology, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0001-7977-9421
Albert SickmannDepartment of Internal Medicine B, University of Münster, Münster, Germany.
André KarchInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0003-3014-8543
Alexander ZarbockDepartment of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-2124-1714
Jens MinnerupDepartment of Neurology, University Hospital Schleswig-Holstein, Lübeck, Germany.
Jürgen SindermannDepartment of Cardiology I, University Hospital Münster, Münster, Germany.
Alexander BenderInstitute of Experimental Pathology (ExPat), Center of Molecular Biology of Inflammation (ZMBE), University of Münster, Münster, Germany.ORCID http://orcid.org/0009-0000-4295-5057
Jan RossaintDepartment of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.
Steffen OrmannsInstitute of General Pathology, Medical University Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0000-0002-0754-9034
Matthias GunzerLeibniz-Institut für Analytische Wissenschaften ISAS - e.V., Dortmund, Germany.
Mariano MalamudInstitute of Experimental Pathology (ExPat), Center of Molecular Biology of Inflammation (ZMBE), University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0001-9754-2399
Rainer KaiserDepartment of Medicine I, University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-1750-3395
Kami PekayvazDepartment of Medicine I, University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-4040-650X
Dominik HeiderInstitute of Medical Informatics, University of Münster, Münster, Germany.
Holger ReineckeDepartment of Cardiology I, University Hospital Münster, Münster, Germany.
Lena MakowskiDepartment of Cardiology I, University Hospital Münster, Münster, Germany.
Christian JungDepartment of Cardiology, Pulmonology and Vascular Medicine, University Hospital and Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.ORCID http://orcid.org/0000-0001-8325-250X
Carlos Silvestre-RoigInstitute of Experimental Pathology (ExPat), Center of Molecular Biology of Inflammation (ZMBE), University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0003-1169-7475
Malte KelmDepartment of Cardiology, Pulmonology and Vascular Medicine, University Hospital and Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
Norbert GerdesDepartment of Cardiology, Pulmonology and Vascular Medicine, University Hospital and Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.ORCID http://orcid.org/0000-0002-4546-7208
Raphael ChevreInstitute of Experimental Pathology (ExPat), Center of Molecular Biology of Inflammation (ZMBE), University of Münster, Münster, Germany.
Stefan A LangeDepartment of Cardiology I, University Hospital Münster, Münster, Germany.
Oliver SoehnleinInstitute of Experimental Pathology (ExPat), Center of Molecular Biology of Inflammation (ZMBE), University of Münster, Münster, Germany. soehnlein@uni-muenster.de.ORCID http://orcid.org/0000-0002-7854-0694

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) TRR332
6 · The paper itself

Abstract

Systemic inflammatory responses shape clinical outcomes in acute cardiovascular disease. Because of their functional plasticity and rapid turnover, neutrophils have emerged as dynamic indicators of inflammatory stress. Here we profile the appearance of distinct neutrophil maturation stages in patients with ST-elevation myocardial infarction, heart failure and stroke. Our data reveal the mobilization of immature neutrophils in all groups; however, patients with ST-elevation myocardial infarction exhibited the most pronounced engagement of this response, including the appearance of CD16

Indexed as

NeutrophilsST Elevation Myocardial InfarctionAgedBiomarkersCytokinesFemaleGPI-Linked ProteinsHeart FailureHumansMaleMiddle AgedPrognosisReceptors, IgGRisk FactorsStrokeTime FactorsBiomarkersCytokinesGPI-Linked ProteinsReceptors, IgG

Identifiers

PMID42399420
PMCPMC13461374

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