Evidence map›Paper›PMID 42399268›Full record

ArticleNature communications2026

Architecture of the Wza-Wzc complex that mediates colanic acid translocation across the cell envelope in Gram-negative bacteria.

Jiao Liu, Yanlong Han, Guanxue Huang, Manfeng Zhang, Junlei Du, Haizhen Zhou, Dahua Chen, Yihua Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiao Liu *State Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Yanlong Han *Polyseq Biotechnology Co., Ltd. (Shaoxing), Building 4, Courtyard 6, North Street, Dongsheng Science and Technology Park, Haidian District, Beijing, China.
Guanxue HuangInstitute of Biomedical Research, Yunnan University, Kunming, China.
Manfeng ZhangPolyseq Biotechnology Co., Ltd. (Shaoxing), Building 4, Courtyard 6, North Street, Dongsheng Science and Technology Park, Haidian District, Beijing, China.
Junlei DuState Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Haizhen ZhouState Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Dahua ChenInstitute of Biomedical Research, Yunnan University, Kunming, China. achendh@ynu.edu.cn.ORCID http://orcid.org/0000-0002-2122-9141
Yihua HuangState Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. yihuahuang@ibp.ac.cn.ORCID http://orcid.org/0000-0001-5910-5972

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Wzx/Wzy-dependent pathway is a highly conserved mechanism for bacterial polysaccharide biosynthesis. This pathway is exemplified by the assembly and export of colanic acid mediated by the Wza-Wzc complex. While recent structural investigations have yielded valuable insights into the molecular basis of colanic acid biosynthesis, the overall architecture of the Wza-Wzc complex and the regulatory mechanism of colanic acid export remain incompletely understood. Here, we report cryo-electron microscopy (cryo-EM) structures of the Wza-Wzc complex from E. coli K12 in two functionally states: the autophosphorylated wild-type (Wza-Wzc

Indexed as

Cell MembraneEscherichia coli K12Escherichia coli ProteinsPolysaccharidesBiological TransportCell WallCryoelectron MicroscopyEscherichia coliPhosphorylationcolanic acidEscherichia coli ProteinsPolysaccharides

Identifiers

PMID42399268
PMCPMC13469938

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.