Evidence map›Paper›PMID 42398998›Full record

ArticleBMJ open2026

ADHD and cardiometabolic risk profile in adults with type 2 diabetes: a longitudinal register-based study.

Zihan Dong, Shengxin Liu, Cecilia Lundholm, Isabell Brikell, Ralf Kuja-Halkola, Brian M D'Onofrio, Paul Lichtenstein, Agnieszka Butwicka, Soffia Gudbjörnsdottir, Henrik Larsson and 2 more

Abstract read
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zihan DongDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden zihan.dong@ki.se.ORCID http://orcid.org/0009-0009-1851-6826
Shengxin LiuDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Cecilia LundholmDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Isabell BrikellDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Ralf Kuja-HalkolaDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Brian M D'OnofrioDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Paul LichtensteinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Agnieszka ButwickaDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Soffia GudbjörnsdottirDepartment of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Henrik LarssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Zheng ChangDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Ebba Du RietzDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the association between attention-deficit/hyperactivity disorder (ADHD) and cardiometabolic risk profile at the time of type 2 diabetes (T2D) diagnosis and examine longitudinal changes in cardiometabolic measures following T2D diagnosis. DESIGN AND

settingA nationwide cohort study using linked Swedish health registers.

participantsAdults aged 18-65 years with a first recorded diagnosis of T2D between 1996 and 2020. ADHD, treated as a lifetime condition, was identified through diagnostic and prescription records. OUTCOME MEASURES: The cardiometabolic risk profile, comprising nine clinical parameters and two behavioural factors, was assessed at T2D diagnosis and was tracked for up to 5 years post-diagnosis. Linear regression (β

resultsAmong 80 607 individuals with T2D, 1204 (1.5%) had an ADHD diagnosis. At T2D diagnosis, individuals with ADHD were younger and had statistically significantly higher body mass index (BMI) (β

conclusionsAmong adults with newly diagnosed T2D, those with co-occurring ADHD had broadly similar cardiometabolic profiles to those without ADHD but presented at a younger age with a modestly higher BMI, triglycerides and smoking prevalence. Individuals with ADHD also showed a slightly greater reduction in BMI over time following T2D diagnosis. Despite modest overall cardiometabolic differences, incorporating ADHD status into preventive diabetes care may help identify a younger, more vulnerable subgroup who could benefit from targeted risk factor management.

Indexed as

Attention Deficit Disorder with HyperactivityCardiometabolic Risk FactorsDiabetes Mellitus, Type 2AdolescentAdultAgedBody Mass IndexFemaleHumansLongitudinal StudiesMaleMiddle AgedRegistriesRisk FactorsSwedenTriglyceridesTriglyceridesAttention Deficit Disorder with HyperactivityBody Mass IndexDiabetes Mellitus, Type 2Lipid disordersSmoking Reduction

Identifiers

PMID42398998
PMCPMC13343064

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.