Evidence map›Paper›PMID 42398936›Full record

ArticleJournal of the American Chemical Society2026

Decoding Galectin-Glycan Recognition with

Milena Bartoloni, Diego Del Balzo, Mirane Florencio-Zabaleta, Marcello Mercogliano, Sara Bertuzzi, Sandra Delgado, Iker Hernández, Mikel Oiarbide, Aitor Landa, Tammo Diercks and 3 more

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Milena BartoloniCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia 48160, Spain.
Diego Del BalzoCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia 48160, Spain.
Mirane Florencio-ZabaletaCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia 48160, Spain.ORCID 0009-0000-6058-2936
Marcello MercoglianoCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia 48160, Spain.
Sara BertuzziCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia 48160, Spain.
Sandra DelgadoCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia 48160, Spain.
Iker HernándezDepartment of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country, EHU, Donostia-San Sebastián 20018, Spain.
Mikel OiarbideDepartment of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country, EHU, Donostia-San Sebastián 20018, Spain.ORCID 0000-0003-0362-0136
Aitor LandaDepartment of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country, EHU, Donostia-San Sebastián 20018, Spain.ORCID 0000-0001-8574-8568
Tammo DiercksCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia 48160, Spain.ORCID 0000-0002-5200-0905
Luca UnioneCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia 48160, Spain.
Jesús Jiménez-BarberoCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia 48160, Spain.ORCID 0000-0001-5421-8513
Ana ArdáCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia 48160, Spain.ORCID 0000-0003-3027-7417

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glycan-lectin interactions at cell surfaces regulate numerous biological processes but remain challenging to characterize at the molecular level. Glycosylation heterogeneity results in lectin-binding targets─from purified glycoproteins to the cell-surface glycocalyx─presenting multiple glycan epitopes simultaneously. Concurrently, distinct lectins often exhibit overlapping glycan binding selectivity, with similar affinities for widely distributed epitopes. Consequently, how lectins compete and achieve selective recognition at glycoprotein and cell-surface levels remains poorly understood. Here, we introduce

Indexed as

GalectinsGlycocalyxLectinsPolysaccharidesHumansGalectinsLectinsPolysaccharides

Identifiers

PMID42398936
PMCPMC13383638

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.