Evidence map›Paper›PMID 42398181›Full record

ArticleEBioMedicine2026

HCV-specific CD4

Samaa T Gobran, Armando Espinosa Ortiz, Omar Khedr, Jessica Dion, Laurence Raymond Marchand, Jonathan Dias, Amélie Cattin, Julie Bruneau, Nicolas Chomont, Marina B Klein and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Samaa T GobranDépartement de Microbiologie, Infectiologie, et Immunologie, Faculté de Médicine, Université de Montréal, Montréal, Québec, Canada; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada; Department of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Armando Espinosa OrtizDépartement de Microbiologie, Infectiologie, et Immunologie, Faculté de Médicine, Université de Montréal, Montréal, Québec, Canada; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.
Omar KhedrCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.
Jessica DionCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.
Laurence Raymond MarchandCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.
Jonathan DiasDépartement de Microbiologie, Infectiologie, et Immunologie, Faculté de Médicine, Université de Montréal, Montréal, Québec, Canada; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.
Amélie CattinDépartement de Microbiologie, Infectiologie, et Immunologie, Faculté de Médicine, Université de Montréal, Montréal, Québec, Canada; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.
Julie BruneauDépartement de Médecine de Famille et de Médecine d'urgence, Faculté de Médicine, Université de Montréal, Montréal, Québec, Canada.
Nicolas ChomontDépartement de Microbiologie, Infectiologie, et Immunologie, Faculté de Médicine, Université de Montréal, Montréal, Québec, Canada; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.
Marina B KleinDepartment of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montréal, Québec, Canada; Division of Infectious Diseases, Department of Medicine, McGill University Health Center (MUHC), Montréal, Québec, Canada.
Petronela AncutaDépartement de Microbiologie, Infectiologie, et Immunologie, Faculté de Médicine, Université de Montréal, Montréal, Québec, Canada; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada. Electronic address: petronela.ancuta@umontreal.ca.
Naglaa H ShoukryCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada; Département de Médecine, Faculté de Médecine, Université de Montréal, Montréal, Québec, Canada. Electronic address: naglaa.shoukry@umontreal.ca.

Funding

Protective immunity to HCV and rational vaccine designU19AI159819 · NIAID · EMORY UNIVERSITY · PI Arash Grakoui · 2021 to 2026
$16.6M
NIAID NIH HHS U19 AI159819
6 · The paper itself

Abstract

backgroundAntiretroviral therapy (ART) reduces human immunodeficiency virus type 1 (HIV-1) replication to undetectable levels but does not eliminate HIV-1 reservoirs, which persist in memory CD4

methodsIn this cross-sectional study, we examined the impact of HCV infection on CD4

findingsMemory CD4

interpretationWe provide evidence that HCV-specific CD4

fundingCanadian Institutes of Health Research (CIHR) (PJT-173467, PJT-153052, PJT-178127, PJT-195736, HB2-164064, BR4-197730, MOP135260, FDN-143270, CTN222 and NHC142832), the National Institutes of Health (NIH) (U19AI159819), and Fonds de recherche du Québec-Santé (FRQS)-Réseau SIDA/maladies infectieuses.

Indexed as

CD4-Positive T-LymphocytesHepacivirusHepatitis CHIV-1HIV InfectionsAdultAnti-Retroviral AgentsCoinfectionCross-Sectional StudiesFemaleHumansMaleMiddle AgedRNA, ViralViral LoadVirus ReplicationAnti-Retroviral AgentsRNA, ViralAntiretroviral therapyCD4(+) T-cellsHepatitis CHIV reservoir

Identifiers

PMID42398181
PMCPMC13351557

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.