Evidence map›Paper›PMID 42397940›Full record

ArticleAngewandte Chemie (International ed. in English)2026

A Domino-Synthesized Dicoordinate Copper(I) Bis-imidazopyridine Complex Triggering Cuproptosis/Ferroptosis for Enhanced Cancer Immunotherapy.

Ning Tian, Haoyu Ju, Yu Liu, Jinmei Huang, Zhenggang Luan, Qifeng Hou, Qing Chen, Bin Zhang, Jin Huang, Ming-Hua Zeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ning TianKey Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, People's Republic of China.
Haoyu JuState Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, Shanghai Frontiers Science Center of Optogenetic Techniques For Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, People's Republic of China.
Yu LiuKey Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, People's Republic of China.
Jinmei HuangKey Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, People's Republic of China.
Zhenggang LuanKey Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, People's Republic of China.
Qifeng HouKey Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, People's Republic of China.
Qing ChenInstitute of Traditional Chinese and Zhuang-Yao Ethnic Medicine, College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, People's Republic of China.
Bin ZhangKey Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, People's Republic of China.
Jin HuangState Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, Shanghai Frontiers Science Center of Optogenetic Techniques For Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, People's Republic of China.ORCID 0000-0002-0698-1693
Ming-Hua ZengKey Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, People's Republic of China.ORCID 0000-0002-7227-7688

Funding

BAGUI Talent Program of Guangxi Province 2019AC26001National Natural Science Foundation of China U23A2080 22171075 82373913 82574463Shanghai Oriental Talent Plan Outstanding Project BJJY2024021STU Scientific Research Initiation Grant NTF26016TTranslational Medicine National Science and Technology Infrastructure (Shanghai) 2024 Open Research Project TMSK-2024-102
6 · The paper itself

Abstract

Novel synthetic methods offer significant potential to accelerate drug development, yet there remains a largely unexplored area for efficiently synthesizing metal-based anticancer agents. Herein, we report a novel solvothermal domino reaction of pyridine-2-methylamine (and its 4-OCH

Indexed as

Antineoplastic AgentsCoordination ComplexesCopperFerroptosisImidazolesImmunotherapyPyridinesAnimalsCuproptosisHumansMiceMolecular StructureAntineoplastic AgentsCoordination ComplexesCopperImidazolesimidazopyridinePyridinescopper complexcuproptosisdomino reactionferroptosisimmunogenic cell death

Identifiers

PMID42397940
PMCPMC13548985

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.