Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
18 authors.
Anthony T NguyenDepartment of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0003-0181-4623
Jolene ViramontesDepartment of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0009-0007-4269-2497
Isaiah VazquezDepartment of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0009-0001-3760-9878
Catriona McWilliamDepartment of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0009-0006-0233-1921
Vaishnavi DevarakondaDepartment of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0009-0009-0114-6152
Regina HensonDepartment of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Wendy L SacksDivision of Endocrinology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jon Mallen-St ClairSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0003-2558-4682
Yufei ChenDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0003-2523-5896
Evan WalgamaSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Kevin S ScherDivision of Medical Oncology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Justin MoyersDivision of Medical Oncology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0001-5139-1652
Howard M SandlerDepartment of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-8193-5769
Julie K JangDepartment of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0001-9120-1235
Zachary S ZumstegDepartment of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0001-7484-3631
Wonwoo ShonDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-4852-4896
Stephen L ShiaoDepartment of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0001-7586-2885
Allen S HoSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0001-5423-509X
Funding
The Impact of Macrophage Polarization on the Efficacy of Radiation TherapyK08CA191139 · NCI · CEDARS-SINAI MEDICAL CENTER · PI SHIAO, STEPHEN L. · 2015 to 2019
$884k
NCI NIH HHS K08 CA191139
6 · The paper itself
Abstract
Lymph node (LN) metastases are a major driver of mortality across solid cancers, including thyroid carcinomas, which are known for high rates of nodal colonization. To elucidate the determinants of nodal spread, we isolated tumor-infiltrating leukocytes from primary thyroid tumors and matched metastatic LNs for single-cell RNA sequencing with validation by multiplex immunohistochemistry. Comparing the microenvironmental alterations between primary tumors and their LNs, we found that thyrocytes and tumor-associated macrophages down-regulate the expression of multiple inflammatory cytokine receptors, including
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Single-cell transcriptomic analysis reveals tumor-immune determinants of lymph node colonization and progression in thyroid cancer. · full record | OpenQuestion