In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Bo ShenDepartment of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, State Key Laboratory of Brain Function and Disorders, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-5701-4652 Linlin HanDepartment of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, State Key Laboratory of Brain Function and Disorders, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0009-0004-6884-5808 Yan XiaoDepartment of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, State Key Laboratory of Brain Function and Disorders, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0001-9430-5654 Cong ShenDepartment of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, State Key Laboratory of Brain Function and Disorders, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0009-0005-5425-3059 Ziwei LeInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Bin WuDepartment of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, State Key Laboratory of Brain Function and Disorders, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0003-4198-1661 Lu SuDepartment of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, State Key Laboratory of Brain Function and Disorders, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0009-0009-4194-946X Wenbo YuDepartment of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, State Key Laboratory of Brain Function and Disorders, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0001-9483-3027 Yimin SunDepartment of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, State Key Laboratory of Brain Function and Disorders, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-3073-6444 Fengtao LiuDepartment of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, State Key Laboratory of Brain Function and Disorders, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0001-7688-1631 Haishan YaoInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0003-4974-9197 Jianjun WuDepartment of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, State Key Laboratory of Brain Function and Disorders, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0001-6438-6334 Jian WangDepartment of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, State Key Laboratory of Brain Function and Disorders, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-2748-395X Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
The subthalamic nucleus (STN) is a prominent target for deep-brain stimulation (DBS) in the treatment of levodopa-induced dyskinesia (LID), a common motor complication of Parkinson's disease. However, the precise impact of STN-DBS on LID remains unclear. Here, we investigated the functional roles of two distinct neuronal populations within the STN in regulating LID. In a mouse model of LID, STN neurons projecting to the entopeduncular nucleus (EP) exhibited a U-shaped activation pattern, whereas those projecting to the tegmental reticular nucleus (RtTg) displayed a predominantly inhibitory response. Activation of EP-projecting STN neurons alleviated dyskinesia but worsened hypokinesia in the parkinsonian state. Activation of RtTg-projecting STN neurons alone did not induce hyperkinetic characteristics, except when combined with levodopa. These findings reveal two anatomically and functionally distinct populations of STN neurons involved in LID regulation, offering insights into the circuitry underlying STN-DBS.
Indexed as
Dyskinesia, Drug-InducedLevodopaNeuronsSubthalamic NucleusAnimalsDeep Brain StimulationDisease Models, AnimalMaleMiceParkinson DiseaseLevodopa
Identifiers
PMID42397913
PMCPMC13330827
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390