Evidence map›Paper›PMID 42397911›Full record

ArticleScience advances2026

Dexterous single sniffs for ethological active olfaction.

Mang Gao, John M Barrett, Rita Fischer, Donald R McCrimmon, Daniel W Wesson, Minghong Ma, Gordon M G Shepherd

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mang GaoDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0009-0002-0379-8655
John M BarrettDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-7524-6035
Rita FischerDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0009-0008-4709-8822
Donald R McCrimmonDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-5339-6043
Daniel W WessonDepartment of Pharmacology and Therapeutics, Florida Chemical Senses Institute, University of Florida College of Medicine, Gainesville, FL, USA.ORCID 0000-0002-3192-3866
Minghong MaDepartment of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-5027-9623
Gordon M G ShepherdDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-1455-8262

Funding

Synaptic circuit organization of motor cortexR37NS061963 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Gordon M Shepherd · 2024 to 2026
$1.6M
Multimodal behavioral analysis of oromanual food-handling in freely moving animalsR34DA059723 · NIDA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SHEPHERD, GORDON M · 2024 to 2025
$714k
NIDA NIH HHS R34 DA059723NINDS NIH HHS R37 NS061963
6 · The paper itself

Abstract

Rhythmic sniffing is considered intrinsic to active olfaction among terrestrial mammals. However, mice are known to briefly hold food under their nares while feeding, suggesting coordination of oromanual dexterity, breathing, and olfaction for nonrhythmic single sniffs. Here, we recorded kinematics and breathing as mice foraged and fed, finding that mice indeed, with clockwork-like dexterity and millisecond timing, synchronize a single inspiration with rapid head and hand movements. These solitary food sniffs are associated with abrupt resetting of the breathing rhythm, differ from stereotypical rhythmic sniffing, and exhibit behavioral modulations for different food properties. Olfactory and motor circuit manipulations demonstrate motor cortical dependence rather than reflexive neural control. Our study extends the concept of active olfaction to include this distinct form of complex motor-sensory coordination, features of which accord with the idea of discrete "snapshot" olfaction.

Indexed as

SmellAnimalsBiomechanical PhenomenaFeeding BehaviorMaleMiceRespiration

Identifiers

PMID42397911
PMCPMC13339859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.