Evidence map›Paper›PMID 42397904›Full record

ArticleScience advances2026

Substance P regulates Tacr1 neurons, which control nitric oxide-mediated neurovascular coupling in the mouse cortex.

Fernanda Juarez Anaya, Jiwon Kim, Sarah E Ross, Alberto L Vazquez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Fernanda Juarez AnayaDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-2399-0687
Jiwon KimDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0009-0008-1668-1273
Sarah E RossDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-2593-3133
Alberto L VazquezDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-5105-9825

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuronal activity-driven increases in cerebral blood flow (CBF), known as neurovascular coupling (NVC), are crucial for sustaining the metabolic demands of the brain. Our group has found that Tacr1 neurons, a subset of somatostatin neurons expressing the substance P (SP) receptor and neuronal nitric oxide synthase (nNOS), exert a disproportionately large regulation of CBF. Here, we use two-photon imaging to show that Tacr1 neurons regulate CBF through nitric oxide (NO) release and SP-receptor signaling . We identify astrocytic calcium (Ca

Indexed as

Cerebral CortexNeuronsNeurovascular CouplingNitric OxideReceptors, Neurokinin-1Substance PAnimalsAstrocytesCalciumCalcium SignalingCerebrovascular CirculationMiceNitric Oxide Synthase Type IVasodilationCalciumNitric OxideNitric Oxide Synthase Type IReceptors, Neurokinin-1Substance P

Identifiers

PMID42397904
PMCPMC13330815

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.