Evidence map›Paper›PMID 42397878›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2026

A Unified Approach for the Synthesis of Conformationally Locked and sp

Ervis Saraci, Federica Plavi, Giovanni Viscardi, Chad N Ungarean, Massimo Boiocchi, Christophe Salome, Quentin Lefebvre, Thomas C Fessard, David Sarlah

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ervis SaraciDepartment of Chemistry, University of Pavia, Pavia, Italy.
Federica PlaviDepartment of Chemistry, University of Pavia, Pavia, Italy.
Giovanni ViscardiDepartment of Chemistry, University of Pavia, Pavia, Italy.
Chad N UngareanDepartment of Chemistry, University of Pavia, Pavia, Italy.
Massimo BoiocchiCentro Grandi Strumenti, University of Pavia, Pavia, Italy.
Christophe SalomeSpiroChem AG, Basel, Switzerland.
Quentin LefebvreSpiroChem AG, Basel, Switzerland.
Thomas C FessardSpiroChem AG, Basel, Switzerland.
David SarlahDepartment of Chemistry, University of Pavia, Pavia, Italy.ORCID https://orcid.org/0000-0002-8736-8953

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aromatics are indispensable structural motifs in pharmaceuticals due to conformational rigidity, unique noncovalent interactions, and stability, but they can also bear negative consequences related to poor solubility and metabolism. On the other hand, sp

Indexed as

benzynebicycleconformational restrictiondiels‐alderhybrids

Identifiers

PMID42397878
PMCPMC13660500

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.