Evidence map›Paper›PMID 42397665›Full record

ArticleJapanese journal of ophthalmology2026

Epidemiology and treatment trends of retinopathy of prematurity: a multi-center study involving four Asian centers and one European center (2016-2023).

Yi-Hsuan Tseng, Tapas Ranjan Padhi, Souvik Bhunia, Sudarshan Seshasai, Andrew Shih-Hsiang Tsai, Gavin Siew-Wei Tan, Nirmal Kavalloor Visruthan, Connie Hong Yee Lai, Tin Yan Grace Hui, Rachel Sze-Wan Yiu and 9 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Japanese journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

19 authors.

Yi-Hsuan TsengDepartment of Medicine, Mackay Medical University, New Taipei City, 252, Taiwan.
Tapas Ranjan PadhiMithu Tulsi Chanrai Campus, L V Prasad Eye Institute, Bhubaneswar, 751016, India.
Souvik BhuniaMithu Tulsi Chanrai Campus, L V Prasad Eye Institute, Bhubaneswar, 751016, India.
Sudarshan SeshasaiSingapore National Eye Center, Singapore, 168751, Singapore.
Andrew Shih-Hsiang TsaiSingapore National Eye Center, Singapore, 168751, Singapore.
Gavin Siew-Wei TanSingapore National Eye Center, Singapore, 168751, Singapore.
Nirmal Kavalloor VisruthanSingapore National Eye Center, Singapore, 168751, Singapore.
Connie Hong Yee LaiDepartment of Ophthalmology, Queen Mary Hospital, Hong Kong, SAR, China.
Tin Yan Grace HuiDepartment of Ophthalmology, University of Hong Kong, Hong Kong, SAR, China.
Rachel Sze-Wan YiuDepartment of Ophthalmology, University of Hong Kong, Hong Kong, SAR, China.
Susana Maria Pereira TeixeiraHospital Professor Doutor Fernando Fonseca, ULSA Amadora-Sintra, Lisbon District, 2720-276, Lisbon, Portugal.
Tomas Reis da CostaHospital Professor Doutor Fernando Fonseca, ULSA Amadora-Sintra, Lisbon District, 2720-276, Lisbon, Portugal.
Pei-Liang WuDepartment of Medicine, National Taiwan University, Taipei City, 10002, Taiwan.
Eugene Yu-Chuan KangCollege of Medicine, Chang Gung University, Taoyuan City, 33302, Taiwan.
Kuan-Jen ChenCollege of Medicine, Chang Gung University, Taoyuan City, 33302, Taiwan.
Nan-Kai WangCollege of Medicine, Chang Gung University, Taoyuan City, 33302, Taiwan.
Yih-Shiou HwangCollege of Medicine, Chang Gung University, Taoyuan City, 33302, Taiwan.
Chi-Chun LaiCollege of Medicine, Chang Gung University, Taoyuan City, 33302, Taiwan.
Wei-Chi WuCollege of Medicine, Chang Gung University, Taoyuan City, 33302, Taiwan. weichi666@gmail.com.

Funding

Chang Gung Memorial Hospital CMRPG3P0051~2Chang Gung Memorial Hospital CMRPG3P0191National Science and Technology Council NSTC 113-2314-B-182A-040
6 · The paper itself

Abstract

purposeTo investigate regional differences in the epidemiology and treatment of retinopathy of prematurity (ROP) from 2016 to 2023. STUDY

designRetrospective multicenter cohort study

methodsPremature infants screened for ROP at a single tertiary referral center in each of five countries/regions (Taiwan, Hong Kong, Singapore, India, and Portugal) during the study period. Demographic characteristics, incidences of ROP and type 1 ROP, and treatment modalities were analyzed. Screening criteria followed local protocols. Logistic regression was used to assess trends, and intergroup comparisons were performed using Kruskal-Wallis and chi-square tests.

resultsA total of 15,031 premature infants were enrolled. Demographics varied significantly (p <0.001); India had the highest gestational age and birth weight, and the lowest proportion of very low birth weight and extremely low birth weight infants with type 1 ROP (p <0.001). Hong Kong had the lowest ROP incidence, while Singapore showed a significant increase over time (p = 0.003). Type 1 ROP rates were higher in Taiwan and India than in Hong Kong and Singapore, with a significant decline observed only in Taiwan (p = 0.005). Anti-Vascular Endothelial Growth Factor (Anti-VEGF) injections were increasingly preferred as initial treatment, with bevacizumab being the most frequently used (87.3%).

conclusionFrom 2016 to 2023, ROP incidence and treatment showed significant regional differences. ROP increased in Singapore, while type 1 ROP decreased significantly in Taiwan. Although anti-VEGF therapy has become more common, laser treatment remains dominant in Hong Kong.

Indexed as

Laser CoagulationRetinopathy of PrematurityAngiogenesis InhibitorsBevacizumabEuropeFemaleGestational AgeHumansIncidenceInfant, NewbornInfant, PrematureIntravitreal InjectionsMaleRetrospective StudiesVascular Endothelial Growth Factor AAngiogenesis InhibitorsBevacizumabVascular Endothelial Growth Factor AAnti-VEGF therapyBevacizumabEpidemiologyLaser photocoagulationRetinopathy of prematurity

Identifiers

PMID42397665

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