ArticleEJNMMI research2026
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Article in EJNMMI research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04202497 (A Phase 1, Open-label, Positron Emission Tomography Study With [18F]MNI-1054 to Determine Lysine-Specific Demethylase 1A Brain Enzyme Occupancy of TAK-418 After Single-Dose Oral Administration in Healthy Subjects), which is not on this map. Not yet cited in PubMed.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase 1, Open-label, Positron Emission Tomography Study With [18F]MNI-1054 to Determine Lysine-Specific Demethylase 1A Brain Enzyme Occupancy of TAK-418 After Single-Dose Oral Administration in Healthy Subjects
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Authors and funding
11 authors.
Funding
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Abstract
backgroundThe enzyme lysine-specific histone demethylase 1 (LSD1) epigenetically regulates gene expression and is a pharmacological target of interest in neurology. The aims of this study were to characterize the novel LSD1 brain PET tracer [
resultsKinetic brain PET data were most accurately modeled by an irreversible two-tissue compartment model. The highest and most reproducible signal was observed in the cerebellum, for which an acquisition time of 120 min was sufficient to maintain accurate and reliable estimates of K
conclusions[
trial registrationhttps://clinicaltrials.gov/study/NCT04202497 , registered 12 December 2019.
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