Evidence map›Paper›PMID 42397539›Full record

ArticleProbiotics and antimicrobial proteins2026

Ligilactobacillus salivarius Lbs57 Exerted Antibacterial Activity and Modulated Cecal Microbiota to Reduce Foodborne Pathogen Campylobacter jejuni.

Yifang Cui, Xu Feng, Yuxin Shao, Jiahe Chen, Fangfang Guo, Dongyan Zhang, Fuzhou Xu

Abstract read
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In one paragraph

Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yifang CuiBeijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Beijing Academy of Agriculture and Forestry Sciences, Institute of Animal Husbandry and Veterinary Medicine, No. 9, Shuguang Huayuan Middle Road, Beijing, 100097, China.
Xu FengBeijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Beijing Academy of Agriculture and Forestry Sciences, Institute of Animal Husbandry and Veterinary Medicine, No. 9, Shuguang Huayuan Middle Road, Beijing, 100097, China.
Yuxin ShaoBeijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Beijing Academy of Agriculture and Forestry Sciences, Institute of Animal Husbandry and Veterinary Medicine, No. 9, Shuguang Huayuan Middle Road, Beijing, 100097, China.
Jiahe ChenBeijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Beijing Academy of Agriculture and Forestry Sciences, Institute of Animal Husbandry and Veterinary Medicine, No. 9, Shuguang Huayuan Middle Road, Beijing, 100097, China.
Fangfang GuoBeijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Beijing Academy of Agriculture and Forestry Sciences, Institute of Animal Husbandry and Veterinary Medicine, No. 9, Shuguang Huayuan Middle Road, Beijing, 100097, China.
Dongyan ZhangBeijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Beijing Academy of Agriculture and Forestry Sciences, Institute of Animal Husbandry and Veterinary Medicine, No. 9, Shuguang Huayuan Middle Road, Beijing, 100097, China. zhdy203@126.com.
Fuzhou XuBeijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Beijing Academy of Agriculture and Forestry Sciences, Institute of Animal Husbandry and Veterinary Medicine, No. 9, Shuguang Huayuan Middle Road, Beijing, 100097, China. xufuzhou@baafs.net.cn.

Funding

the Special Program on Science and Technology Innovation Capacity Building of BAAFS KJCX20251005
6 · The paper itself

Abstract

Campylobacter jejuni (C. jejuni) remains a major global foodborne pathogen, with poultry serving as a primary reservoir. This study evaluates the probiotic potential of Ligilactobacillus salivarius Lbs57 against foodborne pathogen C. jejuni. In vitro, the L. salivarius Lbs57 cell-free supernatant (CFS) exhibited broad-spectrum, thermostable antibacterial activity, with the strongest inhibition against C. jejuni. Characterization revealed the activity was pH and protease-sensitive, and resistant to chemical detergents. Multi-omics analysis, including whole-genome sequencing and peptidomics, identified a two-peptide bacteriocin, salivaricin, as the key antimicrobial agent. In chickens, prophylaxis, continuous, and post-colonization interventions significantly reduced C. jejuni cecal colonization, with achieving a 3-log reduction. Furthermore, L. salivarius Lbs57 modulated the cecal microbiota by increasing diversity and enriching beneficial genera (e.g., Bacteroides, Faecalibacterium) while suppressing pathogens like Clostridium and Streptococcus. Overall, these findings highlight the efficacy of L. salivarius Lbs57 is a promising probiotic candidate for limiting C. jejuni and enhancing gut health in poultry.

Indexed as

Broiler chickenCampylobacter jejuniCecal microbiotaLigilactobacillus salivariusSalivaricin

Identifiers

PMID42397539

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.