Evidence map›Paper›PMID 42397468›Full record

ArticleCVIR endovascular2026

Feasibility pilot study of the use of ultra-low dose iodinated contrast agent for endovascular procedures in patients with chronic limb-threatening ischemia and renal impairment: the ULTRA-LOW study.

Stavros Spiliopoulos, Stavros Grigoriadis, Nikolaos Galanakis, Elias Kehagias, Konstantinos Palialexis, Ornella Moschovaki-Zeiger, Athanasios Giannakis, Ioannis Giannikouris, Petros Nikolopoulos, Constantine N Antonopoulos and 4 more

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Article in CVIR endovascular, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Stavros Spiliopoulos2nd Department of Radiology, Interventional Radiology Unit, Medical School, National and Kapodistrian University of Athens, Attikon" University General Hospital, Athens, Greece. stavspiliop@med.uoa.gr.ORCID http://orcid.org/0000-0003-1860-0568
Stavros Grigoriadis2nd Department of Radiology, Interventional Radiology Unit, Medical School, National and Kapodistrian University of Athens, Attikon" University General Hospital, Athens, Greece.
Nikolaos GalanakisDepartment of Radiology, Medical School, University Hospital of Heraklion, University of Crete, Heraklion, Greece.
Elias KehagiasDepartment of Radiology, Medical School, University Hospital of Heraklion, University of Crete, Heraklion, Greece.
Konstantinos Palialexis2nd Department of Radiology, Interventional Radiology Unit, Medical School, National and Kapodistrian University of Athens, Attikon" University General Hospital, Athens, Greece.
Ornella Moschovaki-Zeiger2nd Department of Radiology, Interventional Radiology Unit, Medical School, National and Kapodistrian University of Athens, Attikon" University General Hospital, Athens, Greece.
Athanasios Giannakis2nd Department of Radiology, Interventional Radiology Unit, Medical School, National and Kapodistrian University of Athens, Attikon" University General Hospital, Athens, Greece.
Ioannis GiannikourisDepartment of Nephrology and Hemodialysis Unit, Mediterraneo Hospital, Glyfada, Athens, Attika, Greece.
Petros NikolopoulosClinical and Interventional Nephrology Unit, Attikon University General Hospital, Chaidari, Attikí, 12462, Greece.
Constantine N Antonopoulos1st Vascular Surgery Department, School of Medicine, National and Kapodistrian University of Athens, Attikon" University Hospital, Athens, Greece.
George Sfyroeras1st Vascular Surgery Department, School of Medicine, National and Kapodistrian University of Athens, Attikon" University Hospital, Athens, Greece.
Konstantinos Moulakakis1st Vascular Surgery Department, School of Medicine, National and Kapodistrian University of Athens, Attikon" University Hospital, Athens, Greece.
Andreas Lazaris1st Vascular Surgery Department, School of Medicine, National and Kapodistrian University of Athens, Attikon" University Hospital, Athens, Greece.
John Kakisis1st Vascular Surgery Department, School of Medicine, National and Kapodistrian University of Athens, Attikon" University Hospital, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the feasibility and safety of an ultra-low-dose iodinated contrast media (CM) protocol during peripheral endovascular procedures in patients with chronic kidney disease (CKD) and chronic limb-threatening ischemia (CLTI). MATERIALS AND

methodsThis prospective, two-center, observational study included consecutive patients with CLTI and renal dysfunction (eGFR < 60 mL/min/1.73m

resultsEighteen patients were enrolled, presenting advanced (Rutherford 6: 38.9%; occlusions: 38.8%) and complex infrainguinal disease (both femoropopliteal and infrapopliteal disease 27.7%; occlusions 38.8%). Technical success was 94.5%, with a mean CM volume of 10.3 ± 3.5 mL (range: 5-17 mL). Procedural success was 100%. No cases of CI-AKI occurred; one patient (5.5%) required dialysis 3 months post-procedure due to disease progression. Mean sCr and eGFR significantly improved at 72 h compared to baseline (p < 0.0001). At 6 months, limb salvage was 94.4%, TLR-free rate was 81.3% and survival was 83.3%.

conclusionUltra-low-dose iodinated CM protocol in complex CLTI endovascular treatment of CKD patients is safe and effective, achieving high technical success without evidence of renal function deterioration. LEVEL OF EVIDENCE: Level 4, Case Series.

Indexed as

AngioplastyChronic limb-threatening ischemiaContrast-associated acute kidney injuryIodinated contrast mediumPeripheral arterial endovascular interventions

Identifiers

PMID42397468
PMCPMC13332077

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.