Evidence map›Paper›PMID 42397436›Full record

ArticleCalcified tissue international2026

ODAPH (p.Arg77*) Phenotype and Onset of Ameloblast Pathology During Postsecretory Transition Demonstrated by FIB-SEM Analyses of Odaph

Jan C-C Hu, Charles E Smith, Hong Zhang, Yuanyuan Hu, Tian Liang, Shih-Kai Wang, Kuan Yu Chu, Evans H Brown, James P Simmer

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Calcified tissue international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jan C-C Hu *Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, 1011 N University Ave, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0002-9294-0248
Charles E Smith *Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, 1011 N University Ave, Ann Arbor, MI, 48109, USA.
Hong ZhangDepartment of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, 1011 N University Ave, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0003-4558-9026
Yuanyuan HuDepartment of Orthodontics and Pediatric Dentistry, University of Michigan School of Dentistry, Ann Arbor, MI, USA.ORCID http://orcid.org/0009-0000-6852-8790
Tian LiangDepartment of Orthodontics and Pediatric Dentistry, University of Michigan School of Dentistry, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3429-7821
Shih-Kai WangDepartment of Dentistry, National Taiwan University School of Dentistry, No.1, Changde St., Taipei City 100, Taiwan.ORCID http://orcid.org/0000-0002-8378-5880
Kuan Yu ChuDepartment of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, 1011 N University Ave, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0009-0001-1619-1097
Evans H BrownDepartment of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, 1011 N University Ave, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0009-0005-4987-3499
James P SimmerDepartment of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, 1011 N University Ave, Ann Arbor, MI, 48109, USA. jsimmer@umich.edu.ORCID http://orcid.org/0000-0002-7192-6105

Funding

NIDCR NIH HHS DE028849
6 · The paper itself

Abstract

Defects in Odontogenesis-Associated Phosphoprotein (ODAPH) cause autosomal recessive non-syndromic amelogenesis imperfecta (AI; OMIM #614832). We present a 14-year-old boy with delayed tooth eruption and generalized soft and yellow enamel. The proband's parents and two siblings were unaffected. Whole exome analyses identified the AI-causing homozygous ODAPH truncation mutation (p.Arg77*) in the proband. Both unaffected parents and one sibling were heterozygous for this change. The other sibling had the reference sequence. To better understand the role of ODAPH in normal amelogenesis and resolve conflicting reports of ODAPH expression and function during postsecretory transition (PST), we performed comprehensive Focused-Ion Beam Scanning Electron Microscopy analyses of continuously growing mandibular incisors from one wild-type and two Odaph

Indexed as

AmeloblastsAmelogenesis ImperfectaPhosphoproteinsAdolescentAmelogenesisAnimalsDental EnamelHumansMaleMiceMicroscopy, Electron, ScanningPhenotypePhosphoproteinsAdhesionAmelogenesis imperfectaCystEnamelMaturation

Identifiers

PMID42397436
PMCPMC13331816

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.