Evidence map›Paper›PMID 42397411›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2026

Single-cell profiling reveals clonal CD8

Hao-Xian Zhu, Fang-Fang Li, Xiao-Min Chen, Bing-Yang Zhang, Ting Xu, Zhe-Xiong Lian, Cai-Yue Gao, Qian-Li Meng

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hao-Xian Zhu *Chronic Disease Laboratory, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China.
Fang-Fang Li *Chronic Disease Laboratory, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China.
Xiao-Min ChenChronic Disease Laboratory, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China.
Bing-Yang ZhangGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Ting XuDepartment of Rheumatology and Immunology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Zhe-Xiong LianGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China. zxlian@gdph.org.cn.
Cai-Yue GaoMedical Research Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China. carolgoh@mail.ustc.edu.cn.
Qian-Li MengChronic Disease Laboratory, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China. mengqly@163.com.

Funding

National Natural Science Foundation of China 82171072National Natural Science Foundation of China 82572046Natural Science Foundation of Jiangxi Province 20244BAB28019
6 · The paper itself

Abstract

backgroundSjögren's disease (SjD) is a chronic progressive autoimmune disorder primarily affecting the exocrine glands. Dacryoadenitis represents one of the typical clinical manifestations of SjD, yet its underlying pathogenic mechanisms remain poorly understood. This study investigated the immune microenvironment of the lacrimal gland to elucidate the pathogenic cell subset and key molecular factors driving SjD-related dacryoadenitis.

methodsAire

resultsWe identified a clonally expanded population of CCL5

conclusionsIFNγ derived from clonally expanded CCL5

Indexed as

CD8-Positive T-LymphocytesDacryocystitisInterferon-gammaSjogren's SyndromeAIRE ProteinAnimalsFemaleLacrimal ApparatusMiceMice, Inbred C57BLMice, KnockoutSingle-Cell AnalysisTranscription FactorsAIRE ProteinIFNG protein, mouseInterferon-gammaTranscription FactorsAutoimmune dacryoadenitisCD8+T cellsIFNγLacrimal glandSjögren disease

Identifiers

PMID42397411

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.