Evidence map›Paper›PMID 42397286›Full record

ArticleJournal of medicinal chemistry2026

Charting New Territory: Systematic Evaluation of the Drug Potential of

Jacopo Garonzi, Gina Wycich, Stefanie Zich, Shakiba Vahdat, Beatriz Carvalho, Guillaume Benoit, Vijay K Ahuja, Claire Le Manach, Hyeonglim Seo, Lionel E Cheruzel and 4 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Synthesis and properties ofChemical science · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jacopo GaronziBioPharma Chemistry, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, Mölndal 43183, Sweden.
Gina WycichInstitute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, Aachen 52074, Germany.
Stefanie ZichBioPharma Chemistry, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, Mölndal 43183, Sweden.
Shakiba VahdatBioPharma Chemistry, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, Mölndal 43183, Sweden.
Beatriz CarvalhoBioPharma Chemistry, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, Mölndal 43183, Sweden.ORCID 0009-0007-0570-6167
Guillaume BenoitBioPharma Chemistry, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, Mölndal 43183, Sweden.ORCID 0009-0004-3353-1171
Vijay K AhujaAssay Profiling and Cell Sciences, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, Mölndal 43183, Sweden.
Claire Le ManachDMPK, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, Mölndal 43183, Sweden.ORCID 0000-0002-9310-0048
Hyeonglim SeoDrug Metabolism and Pharmacokinetics Department, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Lionel E CheruzelDrug Metabolism and Pharmacokinetics Department, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.ORCID 0000-0003-0283-6816
Christian GampeDiscovery Chemistry Department, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.ORCID 0000-0003-4506-5409
Xingyu JiangDiscovery Chemistry Department, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Franziska SchoenebeckInstitute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, Aachen 52074, Germany.ORCID 0000-0003-0047-0929
Stefan SchiesserBioPharma Chemistry, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, Mölndal 43183, Sweden.ORCID 0000-0002-8668-2844

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amides and trifluoromethyl groups are among the most widely used structural motifs in materials science, medicinal chemistry, and agrochemistry. In contrast, their direct combination as

Indexed as

AmidesCarbamatesUreaAnimalsCaco-2 CellsDrug StabilityHumansStructure-Activity RelationshipAmidesCarbamatesUrea

Identifiers

PMID42397286
PMCPMC13403232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.