Trial reportRespirology (Carlton, Vic.)2026
High-Flow Nasal Oxygen in Early Home Pulmonary Rehabilitation for Exertional Hypoxaemia: A Pilot Randomised Feasibility Trial.
Trial report in Respirology (Carlton, Vic.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05752370 (Improving Post-hospitalization Outcomes of Respiratory Patients With Exertional Hypoxemia by Early Pulmonary Rehabilitation Using High Flow Nasal Oxygen- a Pilot Randomized Controlled Trial.), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Post-hospitalization Outcomes of Respiratory Patients With Exertional Hypoxemia by Early Pulmonary Rehabilitation Using High Flow Nasal Oxygen- a Pilot Randomized Controlled Trial.
Who cites it
1 citing paper in PubMed.
- High-Flow Nasal Oxygen in Early Home Pulmonary Rehabilitation for Exertional Hypoxaemia: A Pilot Randomised Feasibility Trial.Respirology (Carlton, Vic.) · 2026Trial
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundPatients with exertional hypoxaemia (EH) at hospital discharge face rapid deconditioning risks. However, early pulmonary rehabilitation (PR) is limited by exercise intolerance and access barriers. Optimal PR design for this group remains unclear. High-flow nasal oxygen (HFO) may alleviate EH, but its role in home-based PR is unexplored. We aimed to evaluate an early, intensive, home-based PR program and the integration of HFO during exercise training for EH patients post-hospitalisation.
methodsIn this pilot feasibility trial, EH patients across respiratory conditions were randomised to PR with HFO (HFO-PR) or PR alone (PR-only). Both groups commenced a three-week home-based PR program (two supervised, three self-directed sessions weekly) within 1 week of discharge. Feasibility was assessed using quantitative and qualitative measures.
resultsFifty-two of 56 patients completed follow-up at 4 weeks. Overall PR program acceptance and uptake were 67% and 62%, respectively. Program completion was lower in the HFO-PR group (60%) compared to the PR-only group (89%), primarily due to reduced adherence to self-directed exercise sessions. Among COPD patients, the 1-min sit-to-stand test at 4 weeks improved by 4.6 repetitions in the HFO group and 5.3 in the PR-only group (adjusted difference in mean change -0.8, 95% CI -4.7 to 3.1). Qualitative findings revealed three themes: Transformations following the intervention, Receiving care and education at home, and Experiencing HFO system. Participants reported challenges with HFO during unsupervised exercise.
conclusionEarly home-based PR for post-hospitalisation EH patients is feasible and safe. However, the addition of HFO was associated with lower adherence, highlighting implementation barriers to address before further evaluation.
trial registrationNCT05752370.
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