SynthesisJournal of neuroendocrinology2026
Alterations in cognitive function among reproductive-age women with polyendocrine metabolic ovarian syndrome: A systematic review and meta-analysis.
Synthesis in Journal of neuroendocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyendocrine metabolic ovarian syndrome (PMOS) is a common endocrine disorder affecting 1.55 million women of reproductive age worldwide. While its physical and reproductive impacts are well-documented, the cognitive effects of PMOS remain under-researched and poorly understood. This systematic review aims to investigate existing literature on cognitive function in women with PMOS. The objective of this review is to identify specific cognitive differences between women with PMOS and those without, highlight gaps in current research and clinical care, and inform the development of more comprehensive care frameworks for individuals with PMOS. A systematic search was conducted using Ovid MEDLINE, Ovid EMBASE, and CINAHL (Cumulative Index to Nursing and Allied Health Literature) for studies published up to June 23, 2025. Eligible studies underwent data extraction and risk of bias assessment in accordance with standard systematic review protocols. Out of 2887 articles screened, 22 studies met the inclusion criteria. Twenty-two studies involving 136,008 women with PMOS and 333,895 without PMOS were included. Across cognitive domains, pooled correlations generally indicated small, non-significant negative associations, including executive function (r = -0.12, 95% confidence interval [CI] -0.26 to 0.02), attention (r = -0.13, 95% CI -0.38 to 0.14), and working memory (r = -0.14, 95% CI -0.31 to 0.05). Substantial heterogeneity was observed in several domains, often driven by individual outlying studies. Risk of bias was generally low, and funnel plots with Egger's regression provided no evidence of publication bias. This review underscores the need for further research into the cognitive aspects of PMOS. Addressing this gap is essential for developing a more comprehensive approach to PMOS treatment and support beyond its traditional focus on physical and reproductive health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.