ArticleAdvanced healthcare materials2026
Multimetal-Doped Nanoenzymes Reprogram Macrophages for Immunotherapy of Gouty Arthritis.
Sui Zhou, Wen-Qian Zhang, Yong Li, Rong-Fen Gao, Jia-Yi Ma, Kai Cheng, Jin-Xuan Fan, Jie Yang, Ling-Li Dong, Bo Liu
Abstract read
In one paragraphArticle in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
10 authors.
Sui ZhouMOE Key Laboratory for Biomedical Photonics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China.
Wen-Qian ZhangDepartment of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China.
Yong LiMOE Key Laboratory for Biomedical Photonics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China.
Rong-Fen GaoDepartment of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China.
Jia-Yi MaDepartment of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China.ORCID https://orcid.org/0009-0003-6586-1901 Kai ChengMOE Key Laboratory for Biomedical Photonics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China.
Jin-Xuan FanMOE Key Laboratory for Biomedical Photonics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China.ORCID https://orcid.org/0000-0002-8434-7591 Jie YangInnovation Institute for Biomedical Materials, College of Nursing and Health Management & College of Life Science and Chemistry, Wuhan Donghu University, Wuhan, Hubei, P. R. China.
Ling-Li DongDepartment of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China.ORCID https://orcid.org/0000-0003-2017-1125 Bo LiuMOE Key Laboratory for Biomedical Photonics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China.ORCID https://orcid.org/0000-0002-5450-5528 Funding
Foundation for Outstanding Young and Middleaged Innovative Research Team in Higher Education Institutions of HuBei Province of China T2022048National Natural Science Foundation of China 62305121National Natural Science Foundation of China 82271847National Natural Science Foundation of China 82373104
6 · The paper itselfAbstract
The deposition of monosodium urate crystals triggers joint inflammation, which serves as a critical factor in gouty arthritis development. However, current monotherapy is unable to simultaneously reduce uric acid and suppress inflammation. We identified through bioinformatics and clinical sample analysis that oxidative stress-related indicators were significantly elevated in patients with gouty arthritis. In light of this clinical finding, we developed a polydopamine-based nanozyme with high superoxide dismutase and catalase activities via bimetallic ion coordination, which was subsequently loaded with uricase, rapamycin, and hyaluronic acid. In the gouty arthritis model, hyaluronic acid could target the CD44 receptor on the surface of macrophages, enhancing nanoprobe accumulation at the joint. The nanoprobe exhibited excellent biocompatibility and eliminated significantly monosodium urate crystals through multienzyme cascade reactions, while simultaneously addressing the accumulation of byproducts such as hydrogen peroxide, thereby markedly alleviating joint swelling and pain. In addition, the levels of Interleukin-1 beta and Interleukin-6 were significantly reduced, and the NF-κB signaling pathway was effectively suppressed. The phenotypic of macrophages was transformed from pro-inflammatory M1 to anti-inflammatory M2 phenotype. Meanwhile, rapamycin effectively suppressed the immunogenicity of uricase and enhanced its therapeutic efficacy in vivo.
Indexed as
Arthritis, GoutyImmunotherapyMacrophagesNanoparticlesAnimalsCatalaseHumansHyaluronic AcidIndolesMaleMicePolymersRAW 264.7 CellsSirolimusSuperoxide DismutaseUrate OxidaseCatalaseHyaluronic AcidIndolespolydopaminePolymersSirolimusSuperoxide DismutaseUrate OxidaseUric Acidgouty arthritisinflammatory microenvironmentmetal‐organic frameworknanozyme
Identifiers
PMID42396921
PMCPMC13474106
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