ReviewDisease models & mechanisms2026
Electrical coupling between transplanted cardiomyocytes and host myocardium to prevent arrhythmia.
Review in Disease models & mechanisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Enhancing the in vitro architecture of human disease.Disease models & mechanisms · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Transplantation of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes offers new opportunities for myocardial repair after infarction. However, as demonstrated in large-animal model studies, such therapy also brings translational challenges, including arrhythmias arising from abnormal spontaneous beating of the engrafted cells or irregular conduction due to poor electrical coupling between host and transplanted tissue. Addressing these issues will have important implications for improving the safety and efficacy of regenerative therapies. This Review summarizes the fundamental mechanisms governing cardiac electrical activity and highlights recent technological advancements for triggering and imaging myocardial electrical function. We focus on emerging experimental platforms that overcome limitations of traditional whole-heart mapping approaches, including organotypic myocardial tissue slices combined with high-resolution optical mapping and optogenetic stimulation. We further discuss recent technological and biological developments in the field of cell transplantation for cardiac repair and examine strategies to manage post-transplant arrhythmia risk, with a particular focus on enhancing graft maturation and electrical integration to accelerate the safe and effective clinical translation of cardiac cell therapies. Finally, we describe recent clinical trials involving transplantation of hiPSC-derived cells into damaged hearts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.