In one paragraphArticle in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
22 authors.
Lucia C PetitoDepartment of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL.ORCID 0000-0002-0156-1219 Xiaoning HuangDivision of Cardiology, Department of Medicine Northwestern University Feinberg School of Medicine Chicago IL.ORCID 0000-0001-5813-5993 C Noel Bairey MerzDepartment of Cardiology Barbra Streisand Women's Heart Center, Smidt Cedars-Sinai Heart Institute Los Angeles CA.ORCID 0000-0002-9933-5155 Natalie BelloDepartment of Cardiology Barbra Streisand Women's Heart Center, Smidt Cedars-Sinai Heart Institute Los Angeles CA.ORCID 0000-0003-3257-3623 Janet CatovDepartment of Obstetrics and Gynecology, Magee-Women's Research Institute and Foundation University of Pittsburg School of Medicine Pittsburgh PA.ORCID 0000-0002-9551-851X Ernesto LiconDivision of Cardiology, Department of Medicine University of California Irvine School of Medicine Irvine CA.
Abbi LaneDepartment of Exercise Science, Arnold School of Public Health University of South Carolina Columbia SC.ORCID 0000-0001-9620-1402 David M HaasDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology Indiana University School of Medicine Indianapolis IN.ORCID 0000-0002-8379-0743 Lisa D LevineDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology University of Pennsylvania School of Medicine Philadelphia PA.ORCID 0000-0002-6811-7980 Uma M ReddyDepartment of Obstetrics and Gynecology Columbia University Irving Medical Center New York NY.
George SaadeDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology Eastern Virginia Medical School Norfolk VA.ORCID 0000-0001-7925-5302 Lauren TheilenDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology University of Utah Health Sciences Center Salt Lake City UT.ORCID 0000-0002-5662-6040 Brian M MercerDepartment of Obstetrics and Gynecology Case Western Reserve University School of Medicine Cleveland OH.
Hyagriv N SimhanDepartment of Obstetrics and Gynecology, Magee-Women's Research Institute and Foundation University of Pittsburg School of Medicine Pittsburgh PA.
Lynn M YeeDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology Northwestern University Feinberg School of Medicine Chicago IL.ORCID 0000-0002-6274-0544 Philip GreenlandDepartment of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL.ORCID 0000-0002-6327-2439 William A GrobmanThe Ohio State University Wexner Medical Center, College of Medicine Columbus OH.
Sadiya S KhanDepartment of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL.ORCID 0000-0003-0643-1859 Funding
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MClinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0MClinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)UM1TR004528 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI GRACE A MCCOMSEY · 2023 to 2026
$32.1MStress and Racial Disparities in Preeclampsia - Clues from DNA Methylomic ProfilingU01HL145358 · NHLBI · RESEARCH TRIANGLE INSTITUTE · PI Philip Greenland, Rebecca Boehm McNeil · 2020 to 2026
$24.6MIndiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3MPreterm Birth in Nulliparous Women: An Understudied Population at Great RiskU10HD063036 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI PARKER, CORETTE BREEDEN · 2010 to 2015
$19.5MPregnancy as a Window to Future Cardiovascular Health: Adverse Pregnancy Outcomes Supplement RequestU10HL119991 · NHLBI · RESEARCH TRIANGLE INSTITUTE · PI PARKER, CORETTE BREEDEN · 2013 to 2018
$12.6MInstitute for Clinical and Translational ScienceUL1TR000153 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M · 2012 to 2015
$12.1MThe Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)U54AG065141 · NIA · CEDARS-SINAI MEDICAL CENTER · PI JAIN, MOHIT · 2020 to 2024
$8.7MWhole-Heart Myocardial Blood Flow Quantification Using MRIR01HL124649 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI LI, DEBIAO · 2015 to 2018
$3.3MPRegnancy OuTcomEs and subclinical Cardiovascular disease sTudy: (PROTECT)R01HL161514 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Sadiya Sana Khan · 2022 to 2026
$3.3MPrevention of Preterm Birth in high Risk Nulliparous PatientsU10HD063047 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WAPNER, RONALD · 2010 to 2014
$1.9MNCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR000153NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1 TR001108NCATS NIH HHS UM1 TR004528NHLBI NIH HHS R01 HL124649NHLBI NIH HHS R01 HL161514NHLBI NIH HHS U01 HL145358NHLBI NIH HHS U10 HL119990NHLBI NIH HHS U10 HL119991NHLBI NIH HHS U10 HL119992NHLBI NIH HHS U10 HL119993NHLBI NIH HHS U10 HL120006NHLBI NIH HHS U10 HL120018NHLBI NIH HHS U10 HL120019NHLBI NIH HHS U10 HL120034NIA NIH HHS U54 AG065141NICHD NIH HHS U10 HD063020NICHD NIH HHS U10 HD063036NICHD NIH HHS U10 HD063037NICHD NIH HHS U10 HD063041NICHD NIH HHS U10 HD063046NICHD NIH HHS U10 HD063047NICHD NIH HHS U10 HD063048NICHD NIH HHS U10 HD063053NICHD NIH HHS U10 HD063072
6 · The paper itselfAbstract
backgroundAdverse pregnancy outcomes (APOs) are associated with increased hypertension risk. Black women experience higher rates of APOs and hypertension compared with White women, but whether APOs contribute to Black-White hypertension disparities remains unknown.
methodsThe nuMoM2b-HHS (Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-To-Be-Heart Health Study) prospectively recruited nulliparous pregnant people at 8 US centers (2010-2013) with follow-up 2 to 7 years postpartum (2014-2017). Race, which represents a social construct, was self-identified. The primary outcome was incident hypertension at follow-up. APOs included hypertensive disorders of pregnancy, preterm birth, and small-for-gestational age birth. Potential confounders (psychological health, social factors, and health behaviors) were assessed via validated questionnaires. We used targeted maximum likelihood-based estimation to estimate Black-White hypertension differences that would remain if racial disparities in APOs were eliminated.
resultsAmong 3335 participants (17% Black; 83% White; mean [SD] age, 27.6 [5.1] years), APO incidence was higher in Black versus White individuals (rate differences [RDs] per 1000 births: hypertensive disorders of pregnancy: 52.5 [95% CI, 20.0-85.1]; preterm birth: 45.4 [95% CI, 20.8-70.1]; small-for-gestational age: 102.4 [95% CI, 75.8-129.1]). Incident hypertension at median 3 years postpartum was higher in Black versus White individuals (RD, 107.1 [95% CI, 69.6-144.4]). APOs mediated the racial disparity in hypertension; eliminating Black-White disparities in APOs would decrease the Black-White disparity in hypertension by 18.2% for hypertensive disorders of pregnancy (RD, 87.6 [95% CI, 36.1-139.2]), 16.3% for preterm birth (RD, 89.6 [95% CI, 41.7-137.6]), and 13.9% for small-for-gestational age (RD, 92.2 [95% CI, 41.6-142.9]).
conclusionsBlack-White differences in hypertension were partially mediated by APOs. APOs may represent a pregnancy-specific pathway contributing to racial disparities in hypertension.
Indexed as
Black or African AmericanHealth Status DisparitiesHypertensionHypertension, Pregnancy-InducedPregnancy OutcomeWhiteAdultFemaleHumansIncidenceInfant, NewbornInfant, Small for Gestational AgePregnancyPremature BirthProspective StudiesRisk Factorsadverse pregnancy outcomeshypertensionpostpartum cardiovascular healthracial disparities
Identifiers
PMID42396788
PMCPMC13477346
What OpenQuestion holds
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