ArticleJournal of the American Heart Association2026
Mesenchymal Stromal Cells Improve Postoperative Cardiac Dysmaturation in a Juvenile Porcine Model.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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13 authors.
Funding
Abstract
backgroundMesenchymal stromal cells (MSCs) are known to protect tissues from inflammation and oxidative stress. This study aimed to evaluate the effects of cardiopulmonary bypass (CPB) and MSC treatment on cardiac maturation in a juvenile porcine model.
methodsTwo-week-old Yorkshire pigs were randomly assigned to 3 groups: (1) control (n=10), (2) CPB (n=10), and (3) CPB + MSC (n=15). MSCs (1 × 10
resultsOxidative stress marker 8-hydroxy-2'-deoxyguanosine (8-OHdG) and Iba1
conclusionsCPB induces oxidative and inflammatory stresses, thereby causing cellular and structural changes in the developing heart. MSC treatment showed promise in improving CPB-induced impairments of cardiac maturation in neonates and infants undergoing cardiac surgery.
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