ArticleFrontiers in cell and developmental biology2026
Matched embryo-endometrium RNA-seq reveals coordinated but asymmetric transcriptomic reprogramming at the onset of early equine pregnancy.
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Maternal recognition of pregnancy (MRP) in the mare requires coordinated adaptations of both the conceptus and the endometrium during the peri-recognition interval; however, integrated transcriptomic analyses of both compartments within the same biological window remain limited. Here, we analyzed conceptus RNA-seq data across embryonic age (Days 8 and 12 post ovulation) and endometrial RNA-seq data across pregnancy status (pregnant versus non-pregnant mares sampled between Days 8 and 12 post ovulation). In pregnant mares, conceptus recovery and endometrial biopsy collection were performed within the same gestation, allowing biological integration of embryo and maternal transcriptomes while preserving tissue-specific statistical contrasts. Results: RNA-seq analysis followed by TMM normalization and voom-limma modeling identified differential expression in both compartments. Differential expression was defined by an adjusted P-value (FDR threshold <0.001). The B-statistic (log-odds of differential expression) was used to prioritize high-confidence candidates for interpretation and downstream modeling, considering genes with a Bayesian posterior probability >1. Gene-level interpretation was restricted to transcripts with a Bayesian posterior probability of differential expression (B > 1). In the conceptus, high-confidence upregulated genes from day 8 to 12 included steroidogenic enzymes ( Conclusion: Matched transcriptomic profiling reveals coordinated but compartment-specific gene regulation at the onset of early equine pregnancy. The conceptus exhibits endocrine and interface specialization, whereas the endometrium demonstrates attenuation of immediate-early transcriptional programs and selective signaling recalibration. These data define a high-confidence systems-level framework for early embryo-maternal communication that precedes the classical maternal recognition phase and is consistent with early embryo-maternal communication associated with the transition toward maternal recognition.
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