Evidence map›Paper›PMID 42396531›Full record

ArticleResearch square2026

Estrogen-related receptor alpha (ERRα) promotes gastrointestinal stromal tumor progression and epithelial-mesenchymal transition through Wnt/β-catenin.

Ronald DeMatteo, Taylor Hartlein, Shan Zeng, Ferdinand Rossi, Montana Morris, Jonathan Sussman, Michael Beckman, Iulia Barbur, Kevin Do, Juan Esteban Perez and 4 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ronald DeMatteoPerelman School of Medicine, University of Pennsylvania.ORCID 0000-0002-7021-8852
Taylor HartleinPerelman School of Medicine, University of Pennsylvania.ORCID 0009-0003-6316-7756
Shan ZengPerelman School of Medicine, University of Pennsylvania.
Ferdinand RossiPerelman School of Medicine, University of Pennsylvania.
Montana MorrisPerelman School of Medicine, University of Pennsylvania.
Jonathan SussmanPerelman School of Medicine, University of Pennsylvania.
Michael BeckmanPerelman School of Medicine, University of Pennsylvania.
Iulia BarburPerelman School of Medicine, University of Pennsylvania.
Kevin DoPerelman School of Medicine, University of Pennsylvania.
Juan Esteban PerezPerelman School of Medicine, University of Pennsylvania.
Gabrielle ColePerelman School of Medicine, University of Pennsylvania.
Danielle FortunaPerelman School of Medicine, University of Pennsylvania.
Jake MlakarHospital of the University of Pennsylvania.
E PeterssonPerelman School of Medicine, University of Pennsylvania.

Funding

Molecular Mechanisms in Gastrointestinal Stromal TumorR01CA102613 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Ronald P. Dematteo · 2004 to 2026
$9.2M
SURGICAL ONCOLOGY RESEARCH TRAINING PROGRAM AT PENNT32CA251063 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Ronald P. Dematteo · 2020 to 2026
$2.6M
NCI NIH HHS R01 CA102613NCI NIH HHS T32 CA251063
6 · The paper itself

Abstract

Gastrointestinal stromal tumor (GIST) is the most common human sarcoma and primarily driven by a gain-of-function mutation in either the KIT or PDGFRA receptor tyrosine kinase. Estrogen-related receptor alpha (ERRα, encoded by

Identifiers

PMID42396531
PMCPMC13321242

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.